Cause of mortality among people with epilepsy in Malaysia: A hospital-based study
Background: This is a follow-up study on mortality in adult patients in Malaysia. This study aimed to determine the cause of death and the factors associated with epilepsy-related death in PWE in Malaysia. Method: Deceased PWE from 2005 to 2020 were identified from the National Registry Department o...
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my.um.eprints.430292023-09-19T04:56:27Z http://eprints.um.edu.my/43029/ Cause of mortality among people with epilepsy in Malaysia: A hospital-based study Khor, Si-Bao Lim, Kheng-Seang Fong, Si-Lei Ho, Jun-Hui Koh, May-Yi Tan, Chong-Tin RC Internal medicine RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Background: This is a follow-up study on mortality in adult patients in Malaysia. This study aimed to determine the cause of death and the factors associated with epilepsy-related death in PWE in Malaysia. Method: Deceased PWE from 2005 to 2020 were identified from the National Registry Department of Malaysia. The details of the cause of death and predictors for epilepsy-related deaths was ascertained from medical records and phone interviews. Result: There were a total of 227 deaths, 144 (63.4%) were male, two (0.9%) underwent autopsy and 46.3% passed away in the community. The majority of deaths (55.5%) were due to causes unrelated to epilepsy. Fortyfive (19.8%) death were related to epilepsy, of which, 22 (9.7%) were due to death directly related to epilepsy including probable SUDEP (5.3%) and status epilepticus (4.4%). The cause of death was unknown in 56 (24.7%) cases. Binary logistic regression analysis identified 3 predictors for epilepsy-related deaths, i.e., structural causes (OR 3.09, 95% CI 1.100-8.691, p = 0.032), younger age of death (OR 2.35, 95% CI 1.039-5.333, p = 0.040) and history of brain surgery (OR 8.09, 95% CI 2.014-32.510, p = 0.003). Twelve (5.3%) had probable SUDEP. The incidence rate of probable SUDEP was 0.42 per 1000 person-years. The majority of them had intellectual disability (9/12), generalized tonic-clonic seizures (9/12), and 2 or more ASMs (9/12). Conclusion: Epilepsy-related deaths accounted for 20% of the deaths in PWE, associated with structural cause, younger age of death, and previous brain surgery. Probable SUDEP is not uncommon in Malaysia and could be under-diagnosed. Elsevier 2022-03 Article PeerReviewed Khor, Si-Bao and Lim, Kheng-Seang and Fong, Si-Lei and Ho, Jun-Hui and Koh, May-Yi and Tan, Chong-Tin (2022) Cause of mortality among people with epilepsy in Malaysia: A hospital-based study. Epilepsy Research, 181. ISSN 0920-1211, DOI https://doi.org/10.1016/j.eplepsyres.2022.106887 <https://doi.org/10.1016/j.eplepsyres.2022.106887>. 10.1016/j.eplepsyres.2022.106887 |
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RC Internal medicine RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Khor, Si-Bao Lim, Kheng-Seang Fong, Si-Lei Ho, Jun-Hui Koh, May-Yi Tan, Chong-Tin Cause of mortality among people with epilepsy in Malaysia: A hospital-based study |
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Background: This is a follow-up study on mortality in adult patients in Malaysia. This study aimed to determine the cause of death and the factors associated with epilepsy-related death in PWE in Malaysia. Method: Deceased PWE from 2005 to 2020 were identified from the National Registry Department of Malaysia. The details of the cause of death and predictors for epilepsy-related deaths was ascertained from medical records and phone interviews. Result: There were a total of 227 deaths, 144 (63.4%) were male, two (0.9%) underwent autopsy and 46.3% passed away in the community. The majority of deaths (55.5%) were due to causes unrelated to epilepsy. Fortyfive (19.8%) death were related to epilepsy, of which, 22 (9.7%) were due to death directly related to epilepsy including probable SUDEP (5.3%) and status epilepticus (4.4%). The cause of death was unknown in 56 (24.7%) cases. Binary logistic regression analysis identified 3 predictors for epilepsy-related deaths, i.e., structural causes (OR 3.09, 95% CI 1.100-8.691, p = 0.032), younger age of death (OR 2.35, 95% CI 1.039-5.333, p = 0.040) and history of brain surgery (OR 8.09, 95% CI 2.014-32.510, p = 0.003). Twelve (5.3%) had probable SUDEP. The incidence rate of probable SUDEP was 0.42 per 1000 person-years. The majority of them had intellectual disability (9/12), generalized tonic-clonic seizures (9/12), and 2 or more ASMs (9/12). Conclusion: Epilepsy-related deaths accounted for 20% of the deaths in PWE, associated with structural cause, younger age of death, and previous brain surgery. Probable SUDEP is not uncommon in Malaysia and could be under-diagnosed. |
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Article |
author |
Khor, Si-Bao Lim, Kheng-Seang Fong, Si-Lei Ho, Jun-Hui Koh, May-Yi Tan, Chong-Tin |
author_facet |
Khor, Si-Bao Lim, Kheng-Seang Fong, Si-Lei Ho, Jun-Hui Koh, May-Yi Tan, Chong-Tin |
author_sort |
Khor, Si-Bao |
title |
Cause of mortality among people with epilepsy in Malaysia: A hospital-based study |
title_short |
Cause of mortality among people with epilepsy in Malaysia: A hospital-based study |
title_full |
Cause of mortality among people with epilepsy in Malaysia: A hospital-based study |
title_fullStr |
Cause of mortality among people with epilepsy in Malaysia: A hospital-based study |
title_full_unstemmed |
Cause of mortality among people with epilepsy in Malaysia: A hospital-based study |
title_sort |
cause of mortality among people with epilepsy in malaysia: a hospital-based study |
publisher |
Elsevier |
publishDate |
2022 |
url |
http://eprints.um.edu.my/43029/ |
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1778161687223861248 |
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13.18916 |