The outcome of the elderly living kidney donors in a single tertiary center in Malaysia

• Main Authors: Goh, En Thong, Jalalonmuhali, Maisarah, Ng, Kok Peng, Wan Md Adnan, Ahmad Hafiz, Hing, Albert (Wong), Cheng, Shian Feng, Ooi, Shok Hoon, Gan, Chye Chung
• Format: Article
• Published: Elsevier Science Inc 2022
• Subjects: QR180 Immunology; RD Surgery
• Online Access: http://eprints.um.edu.my/42967/

Living-kidney transplantation increases with years, however, the rate is comparatively low to support local needs. Marginal living donors like the elderly were used to increase the donor pool. We retrospectively evaluate the outcome of 25 elderly living kidney donors (eLKDs) who were >= 60 years old at the time of donation in our center. Their medical history and laboratory results were analyzed retrospectively from e-medical records. There are 16 females (64.0%) with a median age of 63 (60.5-66.0). The mean follow-up duration was 4.36 +/- 2.46 years. Their mean body mass index increased from 23.70 +/- 3.07 kg/m2 to 24.21 +/- 2.93 kg/m2 (t14] = -2.176, P = .047) post donation. Systolic blood pressure (SBP) increased from 133.33 +/- 11.65 mm Hg to 140.56 +/- 17.78 mm Hg (t17] = -2.124, P = .049). However, the prevalence of overweight and hypertension were not significant. Only 5.56% of the eLKDs developed proteinuria post nephrectomy (P =1.000). Serum creatinine increased from 62.33 +/- 14.39 mmol/L to 104.63 +/- 28.53 mmol/L post 1-month donation (t23] = -9.720, P = .000) and decreased to 99.67 +/- 22.39 mmol/L post 1-year donation (t17] = -8.415, P = .006), and latest results were 94.28 +/- 20.74mmol/L (t17] = -6.630, P = .033). Fasting blood glucose and HbA1c level recorded no significant changes post donation. We noted that 47.62% of the eLKDs had dyslipidemia pre donation, which increased to 76.20% post donation (P = .031). eLKDs with hyperuricemia increased significantly from 5.88% to 52.94%; with uric acid level from 306.12 +/- 68.67 umol/L to 412.24 +/- 74.14 umol/L (t 16] = -7.726, P = .000). None of the eLKDs were diagnosed with metabolic syndrome pre and post kidney donation. Postdonation kidney function of the eLKDs compensated well and were stable in the short term. We noted statistically significant increments of weight, body mass index, SBP, uric acid, and lipid levels, which did not translate to clinical significance post donation. Elderly living-kidney donation can be done safely with close monitoring post donation.