CAR-T Cells/-NK cells in cancer immunotherapy and the potential of MSC to enhance its efficacy: a review

• Main Authors: Chan, Ler Yie, Dass, Sylvia Annabel, Tye, Gee Jun, Imran, Siti A. M., Wan Kamarul Zaman, Wan Safwani, Nordin, Fazlina
• Format: Article
• Published: MDPI 2022
• Subjects: QH301 Biology; RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/42916/

The chimeric antigen receptor (CAR) plays a dynamic role in targeting tumour-associated antigens in cancer cells. This novel therapeutic discovery combines fragments of monoclonal antibodies with the signalling and co-stimulatory domains that have been modified to its current fourth generation. CAR...