Immunohistochemical examination of cytological differentiation in osteosarcomas
In this immunohistochemical examination, the expression of Runx2, Notch1, Delta and Osteopontin peptides were detected in neoplastic cells in 10 Japanese cases of osteosarconia. Immunohistochemically Runx2 peptide expression appeared in the cytoplasm of almost all neoplastic cells of the 10 cases ex...
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my.um.eprints.42812014-10-20T05:22:51Z http://eprints.um.edu.my/4281/ Immunohistochemical examination of cytological differentiation in osteosarcomas Kawakami, T. Shimizu, T. Kimura, A. Hasegawa, H. Siar, C.H. Ng, K.H. Nagatsuka, H. Nagai, N. Kanda, H. RK Dentistry In this immunohistochemical examination, the expression of Runx2, Notch1, Delta and Osteopontin peptides were detected in neoplastic cells in 10 Japanese cases of osteosarconia. Immunohistochemically Runx2 peptide expression appeared in the cytoplasm of almost all neoplastic cells of the 10 cases examined. However, Notch1 peptide expression appeared in the cytoplasm of neoplastic cells in the localized and comparatively well-differentiated area of osteosarcorna, which osteoblastic and chondroblastic containing osteoid and/or chondroid tissues. No expression of Notch1 peptide was detected in the fibroblastic and poorly differentiated areas. Delta peptide appearance was nearly the same pattern of Notch1 peptide. Expression of Osteopontin peptide appeared in almost all cells and the strength expression was shown in the area of comparatively well-differentiated tissues. Therefore, these results suggest that Runx2, Notch1, and Delta peptides are closely related to cytological differentiation or acquisition of tissue specific characteristics in neoplastic cells in osreosarcomas. 2005 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4281/1/Immunohistochemical_examination_of_cytological_differentiation_in_osteosarcomas.pdf application/pdf en http://eprints.um.edu.my/4281/2/Immunohistochemical_examination_of_cytological_differentiation_in_osteosarcomas.pdf Kawakami, T. and Shimizu, T. and Kimura, A. and Hasegawa, H. and Siar, C.H. and Ng, K.H. and Nagatsuka, H. and Nagai, N. and Kanda, H. (2005) Immunohistochemical examination of cytological differentiation in osteosarcomas. European Journal of Medical Research, 10 (11). pp. 475-479. ISSN 0949-2321 |
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RK Dentistry Kawakami, T. Shimizu, T. Kimura, A. Hasegawa, H. Siar, C.H. Ng, K.H. Nagatsuka, H. Nagai, N. Kanda, H. Immunohistochemical examination of cytological differentiation in osteosarcomas |
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In this immunohistochemical examination, the expression of Runx2, Notch1, Delta and Osteopontin peptides were detected in neoplastic cells in 10 Japanese cases of osteosarconia. Immunohistochemically Runx2 peptide expression appeared in the cytoplasm of almost all neoplastic cells of the 10 cases examined. However, Notch1 peptide expression appeared in the cytoplasm of neoplastic cells in the localized and comparatively well-differentiated area of osteosarcorna, which osteoblastic and chondroblastic containing osteoid and/or chondroid tissues. No expression of Notch1 peptide was detected in the fibroblastic and poorly differentiated areas. Delta peptide appearance was nearly the same pattern of Notch1 peptide. Expression of Osteopontin peptide appeared in almost all cells and the strength expression was shown in the area of comparatively well-differentiated tissues. Therefore, these results suggest that Runx2, Notch1, and Delta peptides are closely related to cytological differentiation or acquisition of tissue specific characteristics in neoplastic cells in osreosarcomas. |
format |
Article |
author |
Kawakami, T. Shimizu, T. Kimura, A. Hasegawa, H. Siar, C.H. Ng, K.H. Nagatsuka, H. Nagai, N. Kanda, H. |
author_facet |
Kawakami, T. Shimizu, T. Kimura, A. Hasegawa, H. Siar, C.H. Ng, K.H. Nagatsuka, H. Nagai, N. Kanda, H. |
author_sort |
Kawakami, T. |
title |
Immunohistochemical examination of cytological differentiation in osteosarcomas |
title_short |
Immunohistochemical examination of cytological differentiation in osteosarcomas |
title_full |
Immunohistochemical examination of cytological differentiation in osteosarcomas |
title_fullStr |
Immunohistochemical examination of cytological differentiation in osteosarcomas |
title_full_unstemmed |
Immunohistochemical examination of cytological differentiation in osteosarcomas |
title_sort |
immunohistochemical examination of cytological differentiation in osteosarcomas |
publishDate |
2005 |
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http://eprints.um.edu.my/4281/1/Immunohistochemical_examination_of_cytological_differentiation_in_osteosarcomas.pdf http://eprints.um.edu.my/4281/2/Immunohistochemical_examination_of_cytological_differentiation_in_osteosarcomas.pdf http://eprints.um.edu.my/4281/ |
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13.187197 |