A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950s. Due to the excellent mechanical tribological properties, corrosion resistance, biocompatibility, and antibacterial properties of titanium, it is getting much a...

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Main Authors: Sarraf, Masoud, Rezvani Ghomi, Erfan, Alipour, Saeid, Ramakrishna, Seeram, Sukiman, Nazatul Liana
Format: Article
Published: SPRINGER HEIDELBERG 2022
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Online Access:http://eprints.um.edu.my/42420/
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spelling my.um.eprints.424202023-10-09T08:13:03Z http://eprints.um.edu.my/42420/ A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications Sarraf, Masoud Rezvani Ghomi, Erfan Alipour, Saeid Ramakrishna, Seeram Sukiman, Nazatul Liana TJ Mechanical engineering and machinery Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950s. Due to the excellent mechanical tribological properties, corrosion resistance, biocompatibility, and antibacterial properties of titanium, it is getting much attention as a biomaterial for implants. Furthermore, titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant site. These properties are crucial for producing high-strength metallic alloys for biomedical applications. Titanium alloys are manufactured into the three types of alpha, beta, and alpha + beta. The scientific and clinical understanding of titanium and its potential applications, especially in the biomedical field, are still in the early stages. This review aims to establish a credible platform for the current and future roles of titanium in biomedicine. We first explore the developmental history of titanium. Then, we review the recent advancement of the utility of titanium in diverse biomedical areas, its functional properties, mechanisms of biocompatibility, host tissue responses, and various relevant antimicrobial strategies. Future research will be directed toward advanced manufacturing technologies, such as powder-based additive manufacturing, electron beam melting and laser melting deposition, as well as analyzing the effects of alloying elements on the biocompatibility, corrosion resistance, and mechanical properties of titanium. Moreover, the role of titania nanotubes in regenerative medicine and nanomedicine applications, such as localized drug delivery system, immunomodulatory agents, antibacterial agents, and hemocompatibility, is investigated, and the paper concludes with the future outlook of titanium alloys as biomaterials. SPRINGER HEIDELBERG 2022-04 Article PeerReviewed Sarraf, Masoud and Rezvani Ghomi, Erfan and Alipour, Saeid and Ramakrishna, Seeram and Sukiman, Nazatul Liana (2022) A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications. Bio-Design and Manufacturing, 5 (2). pp. 371-395. ISSN 2096-5524, DOI https://doi.org/10.1007/s42242-021-00170-3 <https://doi.org/10.1007/s42242-021-00170-3>. 10.1007/s42242-021-00170-3
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic TJ Mechanical engineering and machinery
spellingShingle TJ Mechanical engineering and machinery
Sarraf, Masoud
Rezvani Ghomi, Erfan
Alipour, Saeid
Ramakrishna, Seeram
Sukiman, Nazatul Liana
A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
description Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950s. Due to the excellent mechanical tribological properties, corrosion resistance, biocompatibility, and antibacterial properties of titanium, it is getting much attention as a biomaterial for implants. Furthermore, titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant site. These properties are crucial for producing high-strength metallic alloys for biomedical applications. Titanium alloys are manufactured into the three types of alpha, beta, and alpha + beta. The scientific and clinical understanding of titanium and its potential applications, especially in the biomedical field, are still in the early stages. This review aims to establish a credible platform for the current and future roles of titanium in biomedicine. We first explore the developmental history of titanium. Then, we review the recent advancement of the utility of titanium in diverse biomedical areas, its functional properties, mechanisms of biocompatibility, host tissue responses, and various relevant antimicrobial strategies. Future research will be directed toward advanced manufacturing technologies, such as powder-based additive manufacturing, electron beam melting and laser melting deposition, as well as analyzing the effects of alloying elements on the biocompatibility, corrosion resistance, and mechanical properties of titanium. Moreover, the role of titania nanotubes in regenerative medicine and nanomedicine applications, such as localized drug delivery system, immunomodulatory agents, antibacterial agents, and hemocompatibility, is investigated, and the paper concludes with the future outlook of titanium alloys as biomaterials.
format Article
author Sarraf, Masoud
Rezvani Ghomi, Erfan
Alipour, Saeid
Ramakrishna, Seeram
Sukiman, Nazatul Liana
author_facet Sarraf, Masoud
Rezvani Ghomi, Erfan
Alipour, Saeid
Ramakrishna, Seeram
Sukiman, Nazatul Liana
author_sort Sarraf, Masoud
title A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
title_short A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
title_full A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
title_fullStr A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
title_full_unstemmed A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
title_sort state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
publisher SPRINGER HEIDELBERG
publishDate 2022
url http://eprints.um.edu.my/42420/
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score 13.160551