Study protocol: effectiveness of patient centered pharmacist care in improving medication adherence, clinical parameters and quality of life among hemodialysis patients
Background Patients requiring hemodialysis (HD) often have several chronic comorbidities, which necessitate the use of several medications and hence put them at high risk of polypharmacy. Medication-related problems (MRPs) among HD patients are a serious issue as they can increase morbidity and nona...
Saved in:
Main Authors: | , , , , |
---|---|
Format: | Article |
Published: |
Public Library of Science
2022
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/42348/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.um.eprints.42348 |
---|---|
record_format |
eprints |
spelling |
my.um.eprints.423482023-10-13T03:38:07Z http://eprints.um.edu.my/42348/ Study protocol: effectiveness of patient centered pharmacist care in improving medication adherence, clinical parameters and quality of life among hemodialysis patients Paneerselvam, Ganesh Sritheran Aftab, Raja Ahsan Sirisinghe, Roland Gamini Lai, Pauline Siew Mei Lim, Soo Kun R Medicine (General) Background Patients requiring hemodialysis (HD) often have several chronic comorbidities, which necessitate the use of several medications and hence put them at high risk of polypharmacy. Medication-related problems (MRPs) among HD patients are a serious issue as they can increase morbidity and nonadherence with medications. To overcome this issue, a unique pharmacy practice model including medication review (MR) and motivational interviewing (MI) is needed to improve medication adherence, by reducing MRPs and optimizing therapeutic outcomes. The present study aims to assess the effectiveness of MR and MI in improving medication adherence, quality of life (QOL) and clinical outcomes among end-stage renal disease (ESRD) patients who are on dialysis. Method and design This pre-post study will be conducted prospectively among patients with ESRD who have been on dialysis at the Hemodialysis Unit, Hospital Kuala Lumpur and the Hemodialysis Affiliated Centers of the University Malaya Medical Centre, from August 2020 till August 2021. Medication adherence will be assessed using the General Medication Adherence Scale (GMAS), whilst patients' HRQOL will be assessed using the Kidney Disease Quality of Life Short Form 36 (KDQOL-36). Clinical parameters such as blood glucose level, calcium, phosphate, hemoglobin and serum low-density lipoprotein (LDL) levels will be obtained from medical records. A total of 70 patients will be recruited. Discussion We hypothesize that the implementation of pharmacy-based MR and MI may expect an increase in medication adherence scores and increase in HRQOL scores from baseline as well as achieving the clinical lab parameters within the desired range. This would indicate a need for a pharmacist to be involved in the multidisciplinary team to achieve a positive impact on medication adherence among hemodialysis patients. Public Library of Science 2022-02 Article PeerReviewed Paneerselvam, Ganesh Sritheran and Aftab, Raja Ahsan and Sirisinghe, Roland Gamini and Lai, Pauline Siew Mei and Lim, Soo Kun (2022) Study protocol: effectiveness of patient centered pharmacist care in improving medication adherence, clinical parameters and quality of life among hemodialysis patients. PLoS ONE, 17 (2). ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0263412 <https://doi.org/10.1371/journal.pone.0263412>. 10.1371/journal.pone.0263412 |
institution |
Universiti Malaya |
building |
UM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaya |
content_source |
UM Research Repository |
url_provider |
http://eprints.um.edu.my/ |
topic |
R Medicine (General) |
spellingShingle |
R Medicine (General) Paneerselvam, Ganesh Sritheran Aftab, Raja Ahsan Sirisinghe, Roland Gamini Lai, Pauline Siew Mei Lim, Soo Kun Study protocol: effectiveness of patient centered pharmacist care in improving medication adherence, clinical parameters and quality of life among hemodialysis patients |
description |
Background Patients requiring hemodialysis (HD) often have several chronic comorbidities, which necessitate the use of several medications and hence put them at high risk of polypharmacy. Medication-related problems (MRPs) among HD patients are a serious issue as they can increase morbidity and nonadherence with medications. To overcome this issue, a unique pharmacy practice model including medication review (MR) and motivational interviewing (MI) is needed to improve medication adherence, by reducing MRPs and optimizing therapeutic outcomes. The present study aims to assess the effectiveness of MR and MI in improving medication adherence, quality of life (QOL) and clinical outcomes among end-stage renal disease (ESRD) patients who are on dialysis. Method and design This pre-post study will be conducted prospectively among patients with ESRD who have been on dialysis at the Hemodialysis Unit, Hospital Kuala Lumpur and the Hemodialysis Affiliated Centers of the University Malaya Medical Centre, from August 2020 till August 2021. Medication adherence will be assessed using the General Medication Adherence Scale (GMAS), whilst patients' HRQOL will be assessed using the Kidney Disease Quality of Life Short Form 36 (KDQOL-36). Clinical parameters such as blood glucose level, calcium, phosphate, hemoglobin and serum low-density lipoprotein (LDL) levels will be obtained from medical records. A total of 70 patients will be recruited. Discussion We hypothesize that the implementation of pharmacy-based MR and MI may expect an increase in medication adherence scores and increase in HRQOL scores from baseline as well as achieving the clinical lab parameters within the desired range. This would indicate a need for a pharmacist to be involved in the multidisciplinary team to achieve a positive impact on medication adherence among hemodialysis patients. |
format |
Article |
author |
Paneerselvam, Ganesh Sritheran Aftab, Raja Ahsan Sirisinghe, Roland Gamini Lai, Pauline Siew Mei Lim, Soo Kun |
author_facet |
Paneerselvam, Ganesh Sritheran Aftab, Raja Ahsan Sirisinghe, Roland Gamini Lai, Pauline Siew Mei Lim, Soo Kun |
author_sort |
Paneerselvam, Ganesh Sritheran |
title |
Study protocol: effectiveness of patient centered pharmacist care in improving medication adherence, clinical parameters and quality of life among hemodialysis patients |
title_short |
Study protocol: effectiveness of patient centered pharmacist care in improving medication adherence, clinical parameters and quality of life among hemodialysis patients |
title_full |
Study protocol: effectiveness of patient centered pharmacist care in improving medication adherence, clinical parameters and quality of life among hemodialysis patients |
title_fullStr |
Study protocol: effectiveness of patient centered pharmacist care in improving medication adherence, clinical parameters and quality of life among hemodialysis patients |
title_full_unstemmed |
Study protocol: effectiveness of patient centered pharmacist care in improving medication adherence, clinical parameters and quality of life among hemodialysis patients |
title_sort |
study protocol: effectiveness of patient centered pharmacist care in improving medication adherence, clinical parameters and quality of life among hemodialysis patients |
publisher |
Public Library of Science |
publishDate |
2022 |
url |
http://eprints.um.edu.my/42348/ |
_version_ |
1781704630818832384 |
score |
13.18916 |