Vascular function in the aging human brain during muscle exertion
To determine how brain oxygenation is stably maintained during advancing age, cerebral oxygenation and hemoglobin were measured real-time at 10 Hz using near-infrared spectroscopy (NIRS) at rest (30 seconds) and during a 10-repeated handgrip strength test (30 seconds) for 834 adults (M/F = 45/55%) a...
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my.um.eprints.421922023-10-17T01:56:16Z http://eprints.um.edu.my/42192/ Vascular function in the aging human brain during muscle exertion Zhu, Maijian Lee, Tania Xu Yar Hsieh, Yu-Wen Lai, Li-Fan Condello, Giancarlo Donnelly, Cyril J. Smith, Marc Hamzah, Sareena Hanim Lim, Boon-Hooi Huang, Chih-Yang Chi, Nai-Fang Kuo, Chia-Hua SK Hunting sports To determine how brain oxygenation is stably maintained during advancing age, cerebral oxygenation and hemoglobin were measured real-time at 10 Hz using near-infrared spectroscopy (NIRS) at rest (30 seconds) and during a 10-repeated handgrip strength test (30 seconds) for 834 adults (M/F = 45/55%) aged 20-88 y. The amplitude of cerebral hemodynamic fluctuation was reflected by converting 300 values of % oxygen saturation and hemoglobin of each 30-second phase to standard deviation as indicatives of brain oxygenation variability (BOV) and brain hemodynamic variability (BHV) for each participant. Both BOV (+21-72%) and BHV (+94-158%) increased during the maximal voluntary muscle exertions for all age levels (alpha < 0.05), suggesting an increased vascular recruitment to maintain oxygen homeostasis in the brain. Intriguingly, BHV was >100 folds for both resting and challenged conditions (alpha < 0.001) in >80% of adults aged above 50 y despite similar BOV compared with young age counterparts, indicating a huge cost of amplifying hemodynamic oscillation to maintain a stable oxygenation in the aging brain. Since vascular endothelial cells are short-lived, our results implicate a hemodynamic compensation to emergence of daily deficits in replacing senescent endothelial cells after age 50 y. 2022-05 Article PeerReviewed Zhu, Maijian and Lee, Tania Xu Yar and Hsieh, Yu-Wen and Lai, Li-Fan and Condello, Giancarlo and Donnelly, Cyril J. and Smith, Marc and Hamzah, Sareena Hanim and Lim, Boon-Hooi and Huang, Chih-Yang and Chi, Nai-Fang and Kuo, Chia-Hua (2022) Vascular function in the aging human brain during muscle exertion. Aging-us, 14 (9). pp. 3910-3920. ISSN 1945-4589, DOI https://doi.org/10.18632/aging.204052 <https://doi.org/10.18632/aging.204052>. 10.18632/aging.204052 |
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SK Hunting sports Zhu, Maijian Lee, Tania Xu Yar Hsieh, Yu-Wen Lai, Li-Fan Condello, Giancarlo Donnelly, Cyril J. Smith, Marc Hamzah, Sareena Hanim Lim, Boon-Hooi Huang, Chih-Yang Chi, Nai-Fang Kuo, Chia-Hua Vascular function in the aging human brain during muscle exertion |
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To determine how brain oxygenation is stably maintained during advancing age, cerebral oxygenation and hemoglobin were measured real-time at 10 Hz using near-infrared spectroscopy (NIRS) at rest (30 seconds) and during a 10-repeated handgrip strength test (30 seconds) for 834 adults (M/F = 45/55%) aged 20-88 y. The amplitude of cerebral hemodynamic fluctuation was reflected by converting 300 values of % oxygen saturation and hemoglobin of each 30-second phase to standard deviation as indicatives of brain oxygenation variability (BOV) and brain hemodynamic variability (BHV) for each participant. Both BOV (+21-72%) and BHV (+94-158%) increased during the maximal voluntary muscle exertions for all age levels (alpha < 0.05), suggesting an increased vascular recruitment to maintain oxygen homeostasis in the brain. Intriguingly, BHV was >100 folds for both resting and challenged conditions (alpha < 0.001) in >80% of adults aged above 50 y despite similar BOV compared with young age counterparts, indicating a huge cost of amplifying hemodynamic oscillation to maintain a stable oxygenation in the aging brain. Since vascular endothelial cells are short-lived, our results implicate a hemodynamic compensation to emergence of daily deficits in replacing senescent endothelial cells after age 50 y. |
format |
Article |
author |
Zhu, Maijian Lee, Tania Xu Yar Hsieh, Yu-Wen Lai, Li-Fan Condello, Giancarlo Donnelly, Cyril J. Smith, Marc Hamzah, Sareena Hanim Lim, Boon-Hooi Huang, Chih-Yang Chi, Nai-Fang Kuo, Chia-Hua |
author_facet |
Zhu, Maijian Lee, Tania Xu Yar Hsieh, Yu-Wen Lai, Li-Fan Condello, Giancarlo Donnelly, Cyril J. Smith, Marc Hamzah, Sareena Hanim Lim, Boon-Hooi Huang, Chih-Yang Chi, Nai-Fang Kuo, Chia-Hua |
author_sort |
Zhu, Maijian |
title |
Vascular function in the aging human brain during muscle exertion |
title_short |
Vascular function in the aging human brain during muscle exertion |
title_full |
Vascular function in the aging human brain during muscle exertion |
title_fullStr |
Vascular function in the aging human brain during muscle exertion |
title_full_unstemmed |
Vascular function in the aging human brain during muscle exertion |
title_sort |
vascular function in the aging human brain during muscle exertion |
publishDate |
2022 |
url |
http://eprints.um.edu.my/42192/ |
_version_ |
1781704607926321152 |
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13.160551 |