Autoantibody profile in a Malaysian cohort of chronic inflammatory demyelinating polyneuropathy
We report on our cohort of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) who fulfilled the 2010 diagnostic criteria of CIDP. Patients were consecutively recruited and their demographics, clinical features and serological analysis of autoantibodies against neurofascin (NF)-15...
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my.um.eprints.420262023-10-17T01:52:24Z http://eprints.um.edu.my/42026/ Autoantibody profile in a Malaysian cohort of chronic inflammatory demyelinating polyneuropathy Tan, Cheng Yin Goh, Khean Jin Oh, Ai-Wen Devaux, Jerome Shahrizaila, Nortina R Medicine (General) We report on our cohort of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) who fulfilled the 2010 diagnostic criteria of CIDP. Patients were consecutively recruited and their demographics, clinical features and serological analysis of autoantibodies against neurofascin (NF)-155, NF-186, contactin-1 (CNTN1) and contactin-associated protein 1 were obtained. A total of 26 patients for which there was serologic testing were included: 22 typical CIDP, 3 distal CIDP and 1 multifocal CIDP. Of these, 2 patients had previously reported paranodal antibodies; one with autoantibodies IgG4 against NF155 and one with IgG4 against CNTN1. The patient with IgG4 anti-NF155 had young-onset, predominantly distal phenotype with associated tremor and sensory ataxia and poor response to intravenous immunoglobulin (IVIG). The patient with IgG4 anti-CNTN1 antibodies had a subacute onset, sensory ataxia, membranous nephropathy but responded poorly to IVIG. Autoimmune nodopathies represented 8% of our CIDP cohort. The clinical features and treatment response of patients with IgG4 anti-NF155 and anti-CNTN1 were similar to previous reports. Detecting the presence of autoimmune nodopathies was crucial in refining the diagnosis and determining the prognosis. (c) 2022 Elsevier B.V. All rights reserved. Pergamon-Elsevier Science Ltd 2022-03 Article PeerReviewed Tan, Cheng Yin and Goh, Khean Jin and Oh, Ai-Wen and Devaux, Jerome and Shahrizaila, Nortina (2022) Autoantibody profile in a Malaysian cohort of chronic inflammatory demyelinating polyneuropathy. Neuromuscular Disorders, 32 (3). pp. 255-262. ISSN 0960-8966, DOI https://doi.org/10.1016/j.nmd.2022.01.006 <https://doi.org/10.1016/j.nmd.2022.01.006>. https://doi.org/10.1016/j.nmd.2022.01.006 10.1016/j.nmd.2022.01.006 |
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R Medicine (General) Tan, Cheng Yin Goh, Khean Jin Oh, Ai-Wen Devaux, Jerome Shahrizaila, Nortina Autoantibody profile in a Malaysian cohort of chronic inflammatory demyelinating polyneuropathy |
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We report on our cohort of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) who fulfilled the 2010 diagnostic criteria of CIDP. Patients were consecutively recruited and their demographics, clinical features and serological analysis of autoantibodies against neurofascin (NF)-155, NF-186, contactin-1 (CNTN1) and contactin-associated protein 1 were obtained. A total of 26 patients for which there was serologic testing were included: 22 typical CIDP, 3 distal CIDP and 1 multifocal CIDP. Of these, 2 patients had previously reported paranodal antibodies; one with autoantibodies IgG4 against NF155 and one with IgG4 against CNTN1. The patient with IgG4 anti-NF155 had young-onset, predominantly distal phenotype with associated tremor and sensory ataxia and poor response to intravenous immunoglobulin (IVIG). The patient with IgG4 anti-CNTN1 antibodies had a subacute onset, sensory ataxia, membranous nephropathy but responded poorly to IVIG. Autoimmune nodopathies represented 8% of our CIDP cohort. The clinical features and treatment response of patients with IgG4 anti-NF155 and anti-CNTN1 were similar to previous reports. Detecting the presence of autoimmune nodopathies was crucial in refining the diagnosis and determining the prognosis. (c) 2022 Elsevier B.V. All rights reserved. |
format |
Article |
author |
Tan, Cheng Yin Goh, Khean Jin Oh, Ai-Wen Devaux, Jerome Shahrizaila, Nortina |
author_facet |
Tan, Cheng Yin Goh, Khean Jin Oh, Ai-Wen Devaux, Jerome Shahrizaila, Nortina |
author_sort |
Tan, Cheng Yin |
title |
Autoantibody profile in a Malaysian cohort of chronic inflammatory demyelinating polyneuropathy |
title_short |
Autoantibody profile in a Malaysian cohort of chronic inflammatory demyelinating polyneuropathy |
title_full |
Autoantibody profile in a Malaysian cohort of chronic inflammatory demyelinating polyneuropathy |
title_fullStr |
Autoantibody profile in a Malaysian cohort of chronic inflammatory demyelinating polyneuropathy |
title_full_unstemmed |
Autoantibody profile in a Malaysian cohort of chronic inflammatory demyelinating polyneuropathy |
title_sort |
autoantibody profile in a malaysian cohort of chronic inflammatory demyelinating polyneuropathy |
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Pergamon-Elsevier Science Ltd |
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2022 |
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http://eprints.um.edu.my/42026/ https://doi.org/10.1016/j.nmd.2022.01.006 |
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1781704584307146752 |
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13.19449 |