Innate immunity crosstalk with Helicobacter pylori: Pattern recognition receptors and cellular responses
Helicobacter pylori is one of the most successful gastric pathogens that has co-existed with human for centuries. H. pylori is recognized by the host immune system through human pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), C-type lectin like receptors (CLRs), NOD-like re...
Saved in:
Main Authors: | , , , , , |
---|---|
Format: | Article |
Published: |
MDPI
2022
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/41651/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.um.eprints.41651 |
---|---|
record_format |
eprints |
spelling |
my.um.eprints.416512023-10-27T07:52:38Z http://eprints.um.edu.my/41651/ Innate immunity crosstalk with Helicobacter pylori: Pattern recognition receptors and cellular responses Cheok, Yi Ying Tan, Grace Min Yi Lee, Chalystha Yie Qin Abdullah, Suhailah Looi, Chung Yeng Wong, Won Fen QR Microbiology Helicobacter pylori is one of the most successful gastric pathogens that has co-existed with human for centuries. H. pylori is recognized by the host immune system through human pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), C-type lectin like receptors (CLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs), which activate downstream signaling pathways. Following bacterial recognition, the first responders of the innate immune system, including neutrophils, macrophages, and dendritic cells, eradicate the bacteria through phagocytic and inflammatory reaction. This review provides current understanding of the interaction between the innate arm of host immunity and H. pylori, by summarizing H. pylori recognition by PRRs, and the subsequent signaling pathway activation in host innate immune cells. MDPI 2022-07 Article PeerReviewed Cheok, Yi Ying and Tan, Grace Min Yi and Lee, Chalystha Yie Qin and Abdullah, Suhailah and Looi, Chung Yeng and Wong, Won Fen (2022) Innate immunity crosstalk with Helicobacter pylori: Pattern recognition receptors and cellular responses. International Journal of Molecular Sciences, 23 (14). ISSN 1661-6596, DOI https://doi.org/10.3390/ijms23147561 <https://doi.org/10.3390/ijms23147561>. 10.3390/ijms23147561 |
institution |
Universiti Malaya |
building |
UM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaya |
content_source |
UM Research Repository |
url_provider |
http://eprints.um.edu.my/ |
topic |
QR Microbiology |
spellingShingle |
QR Microbiology Cheok, Yi Ying Tan, Grace Min Yi Lee, Chalystha Yie Qin Abdullah, Suhailah Looi, Chung Yeng Wong, Won Fen Innate immunity crosstalk with Helicobacter pylori: Pattern recognition receptors and cellular responses |
description |
Helicobacter pylori is one of the most successful gastric pathogens that has co-existed with human for centuries. H. pylori is recognized by the host immune system through human pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), C-type lectin like receptors (CLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs), which activate downstream signaling pathways. Following bacterial recognition, the first responders of the innate immune system, including neutrophils, macrophages, and dendritic cells, eradicate the bacteria through phagocytic and inflammatory reaction. This review provides current understanding of the interaction between the innate arm of host immunity and H. pylori, by summarizing H. pylori recognition by PRRs, and the subsequent signaling pathway activation in host innate immune cells. |
format |
Article |
author |
Cheok, Yi Ying Tan, Grace Min Yi Lee, Chalystha Yie Qin Abdullah, Suhailah Looi, Chung Yeng Wong, Won Fen |
author_facet |
Cheok, Yi Ying Tan, Grace Min Yi Lee, Chalystha Yie Qin Abdullah, Suhailah Looi, Chung Yeng Wong, Won Fen |
author_sort |
Cheok, Yi Ying |
title |
Innate immunity crosstalk with Helicobacter pylori: Pattern recognition receptors and cellular responses |
title_short |
Innate immunity crosstalk with Helicobacter pylori: Pattern recognition receptors and cellular responses |
title_full |
Innate immunity crosstalk with Helicobacter pylori: Pattern recognition receptors and cellular responses |
title_fullStr |
Innate immunity crosstalk with Helicobacter pylori: Pattern recognition receptors and cellular responses |
title_full_unstemmed |
Innate immunity crosstalk with Helicobacter pylori: Pattern recognition receptors and cellular responses |
title_sort |
innate immunity crosstalk with helicobacter pylori: pattern recognition receptors and cellular responses |
publisher |
MDPI |
publishDate |
2022 |
url |
http://eprints.um.edu.my/41651/ |
_version_ |
1781704703198887936 |
score |
13.18916 |