Fused tricyclic guanidine alkaloids: Insights into their structure, synthesis and bioactivity
A marine natural product possesses a diverse and unique scaffold that contributes to a vast array of bioactivities. Tricyclic guanidine alkaloids are a type of scaffold found only in marine natural products. These rare skeletons exhibit a wide range of biological applications, but their synthetic ap...
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my.um.eprints.413062023-09-18T06:38:56Z http://eprints.um.edu.my/41306/ Fused tricyclic guanidine alkaloids: Insights into their structure, synthesis and bioactivity Abd Rani, Nur Zahirah Lee, Yean Kee Ahmad, Sarfraz Meesala, Ramu Abdullah, Iskandar QD Chemistry A marine natural product possesses a diverse and unique scaffold that contributes to a vast array of bioactivities. Tricyclic guanidine alkaloids are a type of scaffold found only in marine natural products. These rare skeletons exhibit a wide range of biological applications, but their synthetic approaches are still limited. Various stereochemical assignments of the compounds remain unresolved. Batzelladine and ptilocaulins are an area of high interest in research on tricyclic guanidine alkaloids. In addition, mirabilins and netamines are among the other tricyclic guanidine alkaloids that contain the ptilocaulin skeleton. Due to the different structural configurations of batzelladine and ptilocaulin, these two main skeletons are afforded attention in many reports. These two main skeletons exhibit different kinds of compounds by varying their ester chain and sidechain. The synthetic approaches to tricyclic guanidine alkaloids, especially the batzelladine and ptilocaulin skeletons, are discussed. Moreover, this review compiles the first and latest research on the synthesis of these compounds and their bioactivities, dating from the 1980s to 2022. MDPI 2022-09 Article PeerReviewed Abd Rani, Nur Zahirah and Lee, Yean Kee and Ahmad, Sarfraz and Meesala, Ramu and Abdullah, Iskandar (2022) Fused tricyclic guanidine alkaloids: Insights into their structure, synthesis and bioactivity. Marine Drugs, 20 (9). ISSN 1660-3397, DOI https://doi.org/10.3390/md20090579 <https://doi.org/10.3390/md20090579>. 10.3390/md20090579 |
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QD Chemistry Abd Rani, Nur Zahirah Lee, Yean Kee Ahmad, Sarfraz Meesala, Ramu Abdullah, Iskandar Fused tricyclic guanidine alkaloids: Insights into their structure, synthesis and bioactivity |
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A marine natural product possesses a diverse and unique scaffold that contributes to a vast array of bioactivities. Tricyclic guanidine alkaloids are a type of scaffold found only in marine natural products. These rare skeletons exhibit a wide range of biological applications, but their synthetic approaches are still limited. Various stereochemical assignments of the compounds remain unresolved. Batzelladine and ptilocaulins are an area of high interest in research on tricyclic guanidine alkaloids. In addition, mirabilins and netamines are among the other tricyclic guanidine alkaloids that contain the ptilocaulin skeleton. Due to the different structural configurations of batzelladine and ptilocaulin, these two main skeletons are afforded attention in many reports. These two main skeletons exhibit different kinds of compounds by varying their ester chain and sidechain. The synthetic approaches to tricyclic guanidine alkaloids, especially the batzelladine and ptilocaulin skeletons, are discussed. Moreover, this review compiles the first and latest research on the synthesis of these compounds and their bioactivities, dating from the 1980s to 2022. |
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Article |
author |
Abd Rani, Nur Zahirah Lee, Yean Kee Ahmad, Sarfraz Meesala, Ramu Abdullah, Iskandar |
author_facet |
Abd Rani, Nur Zahirah Lee, Yean Kee Ahmad, Sarfraz Meesala, Ramu Abdullah, Iskandar |
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Abd Rani, Nur Zahirah |
title |
Fused tricyclic guanidine alkaloids: Insights into their structure, synthesis and bioactivity |
title_short |
Fused tricyclic guanidine alkaloids: Insights into their structure, synthesis and bioactivity |
title_full |
Fused tricyclic guanidine alkaloids: Insights into their structure, synthesis and bioactivity |
title_fullStr |
Fused tricyclic guanidine alkaloids: Insights into their structure, synthesis and bioactivity |
title_full_unstemmed |
Fused tricyclic guanidine alkaloids: Insights into their structure, synthesis and bioactivity |
title_sort |
fused tricyclic guanidine alkaloids: insights into their structure, synthesis and bioactivity |
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MDPI |
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2022 |
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http://eprints.um.edu.my/41306/ |
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1778161653791064064 |
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13.18916 |