Evolutionary history of Dengue virus type 4: Insights into genotype phylodynamics.
Dengue virus type four (DENV-4) circulates in tropical and subtropical countries from Asia and the Americas. Despite the importance of dengue virus distribution, little is known about the worldwide viral spread. Following a Bayesian phylogenetic approach we inferred the evolutionary history of 310 i...
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| Main Authors: | , |
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| Format: | Article |
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Elsevier
2011
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| Online Access: | http://eprints.um.edu.my/41/ http://www.ncbi.nlm.nih.gov/pubmed/21335103 |
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| Summary: | Dengue virus type four (DENV-4) circulates in tropical and subtropical countries from Asia and the Americas. Despite the importance of dengue virus distribution, little is known about the worldwide viral spread. Following a Bayesian phylogenetic approach we inferred the evolutionary history of 310 isolates sampled from 37 countries during the time period 1956-2008 and the spreading dynamics for genotypes I and II. The region (tropical rainforest biome) comprised by Malaysia-Thailand was the most likely ancestral area from which the serotype has originated and spread. Interestingly, cross-correlation analysis on demographic time series with the Asian sequences showed a statistically significant negative correlation that could be suggestive of competition among genotypes within the same serotype. |
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