MPA alters metabolic phenotype of endometrial cancer-associated fibroblasts from obese women via IRS2 signaling

• Main Authors: Omar, Intan Sofia, Abd Jamil, Amira Hajirah, Adenan, Noor Azmi Mat, Chung, Ivy
• Format: Article
• Published: Public Library of Science 2022
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/40952/

Obese women have a higher risk of developing endometrial cancer (EC) than lean women. Besides affecting EC progression, obesity also affects sensitivity of patients to treatment including medroxprogesterone acetate (MPA). Obese women have a lower response to MPA with an increased risk for tumor recu...