Prognostic abilities of pre- and post-treatment inflammatory markers in oral squamous cell carcinoma: Stepwise modelling
Studies examining the importance of inflammatory markers before treatment as prognosticators of OSCC are available, but information on post-therapy inflammatory markers and their prognostic significance is limited. This study aimed to evaluate the prognostic abilities of pre- and post-treatment infl...
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my.um.eprints.408792023-09-26T02:15:54Z http://eprints.um.edu.my/40879/ Prognostic abilities of pre- and post-treatment inflammatory markers in oral squamous cell carcinoma: Stepwise modelling Zakaria, Sarah Sabrina Ramanathan, Anand Ripen, Zakiah Mat Ghani, Wan Maria Nabillah Yang, Yi-Hsin Vincent-Chong, Vui King Ismail, Siti Mazlipah R Medicine RK Dentistry Studies examining the importance of inflammatory markers before treatment as prognosticators of OSCC are available, but information on post-therapy inflammatory markers and their prognostic significance is limited. This study aimed to evaluate the prognostic abilities of pre- and post-treatment inflammatory markers in patients with OSCC. Materials and Methods: In this retrospective analysis, information on 151 OSCC patients' socio-demographic, clinico-pathological, recurrence, metastasis, and survival data were gathered from clinical records. A multivariable Cox proportional hazards regression (stepwise model) was conducted to identify the prognostic predictors of OS and DFS. The multivariable models' performances were evaluated using Harrell's concordance statistics. Results: For OS, high pre-treatment LMR (HR 3.06, 95%CI 1.56, 5.99), and high post-treatment PLC (HR 3.35, 95%CI 1.71, 6.54) and PLR (HR 5.26, 95%CI 2.62, 10.58) were indicative of a poor prognosis. For DFS, high pre-treatment SII (HR 2.59, 95%CI 1.50, 4.48) and high post-treatment PLC (HR 1.92, 95%CI 1.11, 3.32) and PLR (HR 3.44, 95%CI 1.98, 5.07) were associated with increased mortality. The fitness of the OS and DFS stepwise Cox regression models were proven with a time-dependent AUC of 0.8787 and 0.8502, respectively. Conclusions: High pre-treatment levels of LMR and SII and high post-treatment levels of PLC and PLR are independent predictors of a poor prognosis for patients with OSCC. MDPI 2022-10 Article PeerReviewed Zakaria, Sarah Sabrina and Ramanathan, Anand and Ripen, Zakiah Mat and Ghani, Wan Maria Nabillah and Yang, Yi-Hsin and Vincent-Chong, Vui King and Ismail, Siti Mazlipah (2022) Prognostic abilities of pre- and post-treatment inflammatory markers in oral squamous cell carcinoma: Stepwise modelling. Medicina-Lithuania, 58 (10). ISSN 1010-660X, DOI https://doi.org/10.3390/medicina58101426 <https://doi.org/10.3390/medicina58101426>. 10.3390/medicina58101426 |
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R Medicine RK Dentistry Zakaria, Sarah Sabrina Ramanathan, Anand Ripen, Zakiah Mat Ghani, Wan Maria Nabillah Yang, Yi-Hsin Vincent-Chong, Vui King Ismail, Siti Mazlipah Prognostic abilities of pre- and post-treatment inflammatory markers in oral squamous cell carcinoma: Stepwise modelling |
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Studies examining the importance of inflammatory markers before treatment as prognosticators of OSCC are available, but information on post-therapy inflammatory markers and their prognostic significance is limited. This study aimed to evaluate the prognostic abilities of pre- and post-treatment inflammatory markers in patients with OSCC. Materials and Methods: In this retrospective analysis, information on 151 OSCC patients' socio-demographic, clinico-pathological, recurrence, metastasis, and survival data were gathered from clinical records. A multivariable Cox proportional hazards regression (stepwise model) was conducted to identify the prognostic predictors of OS and DFS. The multivariable models' performances were evaluated using Harrell's concordance statistics. Results: For OS, high pre-treatment LMR (HR 3.06, 95%CI 1.56, 5.99), and high post-treatment PLC (HR 3.35, 95%CI 1.71, 6.54) and PLR (HR 5.26, 95%CI 2.62, 10.58) were indicative of a poor prognosis. For DFS, high pre-treatment SII (HR 2.59, 95%CI 1.50, 4.48) and high post-treatment PLC (HR 1.92, 95%CI 1.11, 3.32) and PLR (HR 3.44, 95%CI 1.98, 5.07) were associated with increased mortality. The fitness of the OS and DFS stepwise Cox regression models were proven with a time-dependent AUC of 0.8787 and 0.8502, respectively. Conclusions: High pre-treatment levels of LMR and SII and high post-treatment levels of PLC and PLR are independent predictors of a poor prognosis for patients with OSCC. |
format |
Article |
author |
Zakaria, Sarah Sabrina Ramanathan, Anand Ripen, Zakiah Mat Ghani, Wan Maria Nabillah Yang, Yi-Hsin Vincent-Chong, Vui King Ismail, Siti Mazlipah |
author_facet |
Zakaria, Sarah Sabrina Ramanathan, Anand Ripen, Zakiah Mat Ghani, Wan Maria Nabillah Yang, Yi-Hsin Vincent-Chong, Vui King Ismail, Siti Mazlipah |
author_sort |
Zakaria, Sarah Sabrina |
title |
Prognostic abilities of pre- and post-treatment inflammatory markers in oral squamous cell carcinoma: Stepwise modelling |
title_short |
Prognostic abilities of pre- and post-treatment inflammatory markers in oral squamous cell carcinoma: Stepwise modelling |
title_full |
Prognostic abilities of pre- and post-treatment inflammatory markers in oral squamous cell carcinoma: Stepwise modelling |
title_fullStr |
Prognostic abilities of pre- and post-treatment inflammatory markers in oral squamous cell carcinoma: Stepwise modelling |
title_full_unstemmed |
Prognostic abilities of pre- and post-treatment inflammatory markers in oral squamous cell carcinoma: Stepwise modelling |
title_sort |
prognostic abilities of pre- and post-treatment inflammatory markers in oral squamous cell carcinoma: stepwise modelling |
publisher |
MDPI |
publishDate |
2022 |
url |
http://eprints.um.edu.my/40879/ |
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1781704537604620288 |
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13.160551 |