The senescence effect of zoledronate on three-dimensional oral mucosa model

• Main Authors: Shaharuddin, Nur Bashira, Jones, Danial, Chai, Wen Lin
• Format: Article
• Published: Penerbit Universiti Kebangsaan Malaysia 2022
• Subjects: R Medicine; RK Dentistry; Oral surgery
• Online Access: http://eprints.um.edu.my/40454/

Zoledronate (ZOL) is an antiresorptive bisphosphonate used to prevent bone loss in skeletal-related disorders, especially in patients with advanced cancer metastatic to bone. However, this medication led to an oral lesion known as medication-related osteonecrosis of the jaw (MRONJ) which also presen...