Zika virus vaccine: The current state of affairs and challenges posed by antibody-dependent enhancement reaction

• Main Authors: Cheong, Heng Choon, Cheok, Yi Ying, Chan, Yee Teng, Sulaiman, Sofiah, Looi, Chung Yeng, Alshanon, Ahmed F., Hassan, Jamiyah, Abu Bakar, Sazaly, Wong, Won Fen
• Format: Article
• Published: Mary Ann Liebert, Inc 2022
• Subjects: QR Microbiology; RA Public aspects of medicine
• Online Access: http://eprints.um.edu.my/40374/

Infection caused by the Zika virus (ZIKV) can lead to serious neurological complications such as microcephaly in neonates. At present, no approved ZIKV vaccine is available, but few vaccine candidates are undergoing clinical trial. One major challenge faced is antibody-dependent enhancement (ADE) re...