Quorum sensing in aeromonas species isolated from patients in Malaysia
Bacterial quorum sensing signal molecules called N-acylhomoserine lactone (AHL) controls the expression of virulence determinants in many Gram-negative bacteria. We determined AHL production in 22 Aeromonas strains isolated from various infected sites from patients (bile, blood, peritoneal fluid, pu...
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my.um.eprints.38452019-12-23T05:43:09Z http://eprints.um.edu.my/3845/ Quorum sensing in aeromonas species isolated from patients in Malaysia Chan, Kok Gan Puthucheary, Savithri Devi Chan, Xin Yue Yin, Wai Fong Wong, Cheng Siang Too, Wah Seng See Chua, Kek Heng R Medicine Bacterial quorum sensing signal molecules called N-acylhomoserine lactone (AHL) controls the expression of virulence determinants in many Gram-negative bacteria. We determined AHL production in 22 Aeromonas strains isolated from various infected sites from patients (bile, blood, peritoneal fluid, pus, stool and urine). All isolates produced the two principal AHLs, N-butanoylhomoserine lactone (C4-HSL) and N-hexanoyl homoserine lactone (C6-HSL). Ten isolates also produced additional AHLs. This report is the first documentation of Aeromonas sobria producing C6-HSL and two additional AHLs with N-acyl side chain longer than C(6). Our data provides a better understanding of the mechanism(s) of this environmental bacterium emerging as a human pathogen. 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3845/1/Quorum_sensing_in_Aeromonas_species_isolated_from_patients_in_Malaysia..pdf Chan, Kok Gan and Puthucheary, Savithri Devi and Chan, Xin Yue and Yin, Wai Fong and Wong, Cheng Siang and Too, Wah Seng See and Chua, Kek Heng (2011) Quorum sensing in aeromonas species isolated from patients in Malaysia. Current microbiology, 62 (1). pp. 167-172. ISSN 0343-8651 |
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R Medicine Chan, Kok Gan Puthucheary, Savithri Devi Chan, Xin Yue Yin, Wai Fong Wong, Cheng Siang Too, Wah Seng See Chua, Kek Heng Quorum sensing in aeromonas species isolated from patients in Malaysia |
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Bacterial quorum sensing signal molecules called N-acylhomoserine lactone (AHL) controls the expression of virulence determinants in many Gram-negative bacteria. We determined AHL production in 22 Aeromonas strains isolated from various infected sites from patients (bile, blood, peritoneal fluid, pus, stool and urine). All isolates produced the two principal AHLs, N-butanoylhomoserine lactone (C4-HSL) and N-hexanoyl homoserine lactone (C6-HSL). Ten isolates also produced additional AHLs. This report is the first documentation of Aeromonas sobria producing C6-HSL and two additional AHLs with N-acyl side chain longer than C(6). Our data provides a better understanding of the mechanism(s) of this environmental bacterium emerging as a human pathogen. |
format |
Article |
author |
Chan, Kok Gan Puthucheary, Savithri Devi Chan, Xin Yue Yin, Wai Fong Wong, Cheng Siang Too, Wah Seng See Chua, Kek Heng |
author_facet |
Chan, Kok Gan Puthucheary, Savithri Devi Chan, Xin Yue Yin, Wai Fong Wong, Cheng Siang Too, Wah Seng See Chua, Kek Heng |
author_sort |
Chan, Kok Gan |
title |
Quorum sensing in aeromonas species isolated from patients in Malaysia |
title_short |
Quorum sensing in aeromonas species isolated from patients in Malaysia |
title_full |
Quorum sensing in aeromonas species isolated from patients in Malaysia |
title_fullStr |
Quorum sensing in aeromonas species isolated from patients in Malaysia |
title_full_unstemmed |
Quorum sensing in aeromonas species isolated from patients in Malaysia |
title_sort |
quorum sensing in aeromonas species isolated from patients in malaysia |
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2011 |
url |
http://eprints.um.edu.my/3845/1/Quorum_sensing_in_Aeromonas_species_isolated_from_patients_in_Malaysia..pdf http://eprints.um.edu.my/3845/ |
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