Synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent for CT/ fluorescence bi-modal imaging application
Bi-modal imaging contrast agent has attracted considerable attention in medical physics research field via quantum dots (QDs) fabrications. Doped quantum dots are playing an important role in seeking alternatives to conventional heavy metal-containing particles for medical applications. In order to...
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my.um.eprints.382962024-05-07T04:30:32Z http://eprints.um.edu.my/38296/ Synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent for CT/ fluorescence bi-modal imaging application Alhasan, Ammar Sani, S. F. Abdul Tajuddin, Hairul Anuar Ali, Tammar Hussein Hisham, Shameer Ung, Ngie Min Azhar, Nurul Amniyyah Said, Nur Akmarina B. M. Jamil, Amira Hajirah Abd Bradley, D. A. QC Physics QD Chemistry Bi-modal imaging contrast agent has attracted considerable attention in medical physics research field via quantum dots (QDs) fabrications. Doped quantum dots are playing an important role in seeking alternatives to conventional heavy metal-containing particles for medical applications. In order to improve imaging diagnosis, herein we report the design and synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent. The medium, mercaptopropionic acid (MPA) capped Mn:ZnSe QDs surface-conjugated with a commercial contrast agent (Iohexol), was synthesized in seeking to overcome the limitations of Iohexol, also towards advancing bi-modal imaging approaches. In this study, morphology, elemental, absorption and fluorescence analysis were investi-gated, followed by a preliminary study of CT contrast enhancement and cell viability. In comparison to Iohexol, the fluorescence of I@MPA-Mn:ZnSe is observed at 585 nm. The CT Hounsfield unit (HU) increases linearly with mass concentration, with a four-fold increment in HU over that of Iohexol, producing greater than 328 Delta HU at similar concentrations, confirming the CT contrast efficiency of I@MPA-Mn:ZnSe. Cytotoxicity studies have confirmed that the medium possesses good biocompatibility and low toxicity to cells (HepG2 and MDA-MB-321). Present results for CT enhancement and brightness of fluorescence of I@MPA-Mn:ZnSe point to its great potential as a bi-modal contrast medium for further diagnosis applications. Elsevier 2023-08 Article PeerReviewed Alhasan, Ammar and Sani, S. F. Abdul and Tajuddin, Hairul Anuar and Ali, Tammar Hussein and Hisham, Shameer and Ung, Ngie Min and Azhar, Nurul Amniyyah and Said, Nur Akmarina B. M. and Jamil, Amira Hajirah Abd and Bradley, D. A. (2023) Synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent for CT/ fluorescence bi-modal imaging application. Radiation Physics and Chemistry, 209. ISSN 0969-806X, DOI https://doi.org/10.1016/j.radphyschem.2023.110947 <https://doi.org/10.1016/j.radphyschem.2023.110947>. 10.1016/j.radphyschem.2023.110947 |
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QC Physics QD Chemistry Alhasan, Ammar Sani, S. F. Abdul Tajuddin, Hairul Anuar Ali, Tammar Hussein Hisham, Shameer Ung, Ngie Min Azhar, Nurul Amniyyah Said, Nur Akmarina B. M. Jamil, Amira Hajirah Abd Bradley, D. A. Synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent for CT/ fluorescence bi-modal imaging application |
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Bi-modal imaging contrast agent has attracted considerable attention in medical physics research field via quantum dots (QDs) fabrications. Doped quantum dots are playing an important role in seeking alternatives to conventional heavy metal-containing particles for medical applications. In order to improve imaging diagnosis, herein we report the design and synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent. The medium, mercaptopropionic acid (MPA) capped Mn:ZnSe QDs surface-conjugated with a commercial contrast agent (Iohexol), was synthesized in seeking to overcome the limitations of Iohexol, also towards advancing bi-modal imaging approaches. In this study, morphology, elemental, absorption and fluorescence analysis were investi-gated, followed by a preliminary study of CT contrast enhancement and cell viability. In comparison to Iohexol, the fluorescence of I@MPA-Mn:ZnSe is observed at 585 nm. The CT Hounsfield unit (HU) increases linearly with mass concentration, with a four-fold increment in HU over that of Iohexol, producing greater than 328 Delta HU at similar concentrations, confirming the CT contrast efficiency of I@MPA-Mn:ZnSe. Cytotoxicity studies have confirmed that the medium possesses good biocompatibility and low toxicity to cells (HepG2 and MDA-MB-321). Present results for CT enhancement and brightness of fluorescence of I@MPA-Mn:ZnSe point to its great potential as a bi-modal contrast medium for further diagnosis applications. |
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Article |
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Alhasan, Ammar Sani, S. F. Abdul Tajuddin, Hairul Anuar Ali, Tammar Hussein Hisham, Shameer Ung, Ngie Min Azhar, Nurul Amniyyah Said, Nur Akmarina B. M. Jamil, Amira Hajirah Abd Bradley, D. A. |
author_facet |
Alhasan, Ammar Sani, S. F. Abdul Tajuddin, Hairul Anuar Ali, Tammar Hussein Hisham, Shameer Ung, Ngie Min Azhar, Nurul Amniyyah Said, Nur Akmarina B. M. Jamil, Amira Hajirah Abd Bradley, D. A. |
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Alhasan, Ammar |
title |
Synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent for CT/ fluorescence bi-modal imaging application |
title_short |
Synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent for CT/ fluorescence bi-modal imaging application |
title_full |
Synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent for CT/ fluorescence bi-modal imaging application |
title_fullStr |
Synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent for CT/ fluorescence bi-modal imaging application |
title_full_unstemmed |
Synthesis of I@MPA-Mn:ZnSe as an efficient contrast agent for CT/ fluorescence bi-modal imaging application |
title_sort |
synthesis of i@mpa-mn:znse as an efficient contrast agent for ct/ fluorescence bi-modal imaging application |
publisher |
Elsevier |
publishDate |
2023 |
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http://eprints.um.edu.my/38296/ |
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1800082899144278016 |
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13.18916 |