Mutation analysis of the BRCA1 gene in Malaysian breast cancer patients

• Main Authors: Balraj, P., Khoo, A.S.B., Volpi, L., Tan, J.A.M.A., Nair, S., Abdullah, H.
• Format: Article
• Language: English
• Published: Stamford Publishing Pte Ltd / Singapore Medical Association 2002
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/3725/1/Mutational_analysis_of_the_BRCA1_gene_in.pdf; http://eprints.um.edu.my/3725/

Thirty patients with early onset breast cancer or familial breast cancer from Malaysia were analysed for germline mutation in the early onset breast cancer I gene (BRCA1). Direct sequencing of the entire coding region of BRCA1 identified a frameshift mutation, c.5447-5448insC (insC5447) (codon 1776...