Screening of concurrent alpha-Thalassaemia 1 in beta-Thalassaemia carriers
Thalassaemia is an inherited blood disorder and is a significant public health problem in Malaysia, with many not knowing they carry gene for thalassaemia. The two major forms are alpha and beta thalassaemia. An individual can co-inherit both the alpha and beta thalassaemia genes. This study determi...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Malaysian Medical Association
2006
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/3716/1/Screening_of_Concurrent_alpha-thalassemia_1.pdf http://eprints.um.edu.my/3716/ |
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| Summary: | Thalassaemia is an inherited blood disorder and is a significant public health problem in Malaysia, with many not knowing they carry gene for thalassaemia. The two major forms are alpha and beta thalassaemia. An individual can co-inherit both the alpha and beta thalassaemia genes. This study determined the frequency of cincurrent carriers of alpha thalassaemia in 231 beta thalassaemia carriers. Gap-PCR was done on extracted DNA of the beta thalassaemia samples to check for alpha thalassaemia 1 molecular defect. Eight (3.5) samples were found to have concurrently inherited the alpha thalassaemia 1 deletion. The significant carrier rare for alpha thalassaemia 1 indicates the need for the implementation of DNA analysis to complement thalassaemia screening in high risk populations. |
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