Deregulation of lysophosphatidic acid metabolism in oral cancer promotes cell migration via the up-regulation of COX-2

• Main Authors: Rahman, Mariati Abdul, Tan, May Leng, Johnson, Steven P., Hollows, Robert J., Chai, Wen Lin, Mansell, Jason P., Yap, Lee Fah, Paterson, Ian C.
• Format: Article
• Published: PeerJ Inc. 2020
• Subjects: RK Dentistry; Oral surger
• Online Access: http://eprints.um.edu.my/36263/

Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide and accounts for 300,000 new cases yearly. The five-year survival rate is approximately 50% and the major challenges to improving patient prognosis include late presentation, treatment resistance, second primary tumours an...