Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore-based virtual screening approach

• Main Authors: Mirza, Muhammad Usman, Saadabadi, Atefeh, Vanmeert, Michiel, Salo-Ahen, Outi M. h, Abdullah, Iskandar, Claes, Sandra, De Jonghe, Steven, Schols, Dominique, Ahmad, Sarfraz, Froeyen, Matheus
• Format: Article
• Published: Elsevier 2020
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/36234/; https://www.scopus.com/record/display.uri?eid=2-s2.0-85090592677&origin=resultslist&sort=plf-f&src=s&sid=5bb9011e0f974ea6939427354bd1c316&sot=b&sdt=b&s=TITLE-ABS-KEY%28Discovery+of+HIV+entry+inhibitors+via+a+hybrid+CXCR4+and+CCR5+receptor+pharmacophore-based+virtual+screening+approach%29&sl=132&sessionSearchId=5bb9011e0f974ea6939427354bd1c316

Chemokine receptors are key regulators of cell migration in terms of immunity and inflammation. Among these, CCR5 and CXCR4 play pivotal roles in cancer metastasis and HIV-1 transmission and infection. They act as essential co-receptors for HIV and furnish a route to the cell entry. In particular, i...