Use of composite outcomes in neonatal trials: An analysis of the Cochrane reviews

• Main Authors: Lai, Nai Ming, Yap, Amanda Qiao Ying, Ong, Hwee Chin, Wai, Sheng Xuan, Yeo, Julie Hsiao Hui, Koo, Charis Yen Ee, Lah, Wen Chin, Lim, Yin Sear, Ovelman, Colleen, Soll, Roger F.
• Format: Article
• Published: Karger Publishers 2021
• Subjects: R Medicine; RJ Pediatrics
• Online Access: http://eprints.um.edu.my/35952/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103548652&doi=10.1159%2f000514402&partnerID=40&md5=3016867df4f655592809b02659e16408

Composite outcomes are used to increase the power of a study by combining event rates. Many composite outcomes in adult clinical trials have components that differ substantially in patient importance, event rate, and effect size, making interpretation challenging. Little is known about the use of co...