Time-domain NMR analysis for the determination of water content in pharmaceutical ingredients and wet granules

• Main Authors: Ohgi, Kosuke, Hayashi, Yoshihiro, Tsuji, Takahiro, Ito, Terushi, Leong, Kok Hoong, Usuda, Shui, Kumada, Shungo, Okada, Kotaro, Onuki, Yoshinori
• Format: Article
• Published: Elsevier 2021
• Subjects: R Medicine; RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/35358/

The application of time-domain NMR (TD-NMR) analysis to quantify water content in pharmaceutical ingredients is demonstrated. The initial phase of the study employed a range of disintegrants with defined amounts of added water (0-30% of the total weight) as samples; the disintegrants included crosca...