Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm)
Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing pu...
Saved in:
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Published: |
Springernature
2021
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/35066/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.um.eprints.35066 |
---|---|
record_format |
eprints |
spelling |
my.um.eprints.350662022-09-09T00:20:13Z http://eprints.um.edu.my/35066/ Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm) Runcharoen, Chakkaphan Fukunaga, Koya Sensorn, Insee Iemwimangsa, Nareenart Klumsathian, Sommon Tong, Hang Vo, Nam Sy Le, Ly Hlaing, Tin Maung Thant, Myo Mohd Zain, Shamsul Mohamed, Zahurin Pung, Yuh-Fen Capule, Francis Nevado, Jose Silao, Catherine Lynn Al-Mahayri, Zeina N. Ali, Bassam R. Yuliwulandari, Rika Prayuni, Kinasih Zahroh, Hilyatuz Noor, Dzul Azri Mohamed Xangsayarath, Phonepadith Xayavong, Dalouny Kounnavong, Sengchanh Sayasone, Somphou Kordou, Zoe Liopetas, Ioannis Tsikrika, Athina Tsermpini, Evangelia-Eirini Koromina, Maria Mitropoulou, Christina Patrinos, George P. Kesornsit, Aumpika Charoenyingwattana, Angkana Wattanapokayakit, Sukanya Mahasirimongkol, Surakameth Mushiroda, Taisei Chantratita, Wasun BF Psychology QH426 Genetics Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. A panel of 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using the NGS platform under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Here, we present the frequencies of pharmacogenomic variants and the comparison of these pharmacogenomic variants among different SEA populations and other populations used as controls. We investigated the different types of pharmacogenomic variants, especially those that may have a functional impact. Our results provide substantial genetic variations at 100 pharmacogenomic loci among SEA populations that may contribute to interpopulation variability in drug response phenotypes. Correspondingly, this study provides basic information for further pharmacogenomic investigations in SEA populations. Springernature 2021-02-04 Article PeerReviewed Runcharoen, Chakkaphan and Fukunaga, Koya and Sensorn, Insee and Iemwimangsa, Nareenart and Klumsathian, Sommon and Tong, Hang and Vo, Nam Sy and Le, Ly and Hlaing, Tin Maung and Thant, Myo and Mohd Zain, Shamsul and Mohamed, Zahurin and Pung, Yuh-Fen and Capule, Francis and Nevado, Jose and Silao, Catherine Lynn and Al-Mahayri, Zeina N. and Ali, Bassam R. and Yuliwulandari, Rika and Prayuni, Kinasih and Zahroh, Hilyatuz and Noor, Dzul Azri Mohamed and Xangsayarath, Phonepadith and Xayavong, Dalouny and Kounnavong, Sengchanh and Sayasone, Somphou and Kordou, Zoe and Liopetas, Ioannis and Tsikrika, Athina and Tsermpini, Evangelia-Eirini and Koromina, Maria and Mitropoulou, Christina and Patrinos, George P. and Kesornsit, Aumpika and Charoenyingwattana, Angkana and Wattanapokayakit, Sukanya and Mahasirimongkol, Surakameth and Mushiroda, Taisei and Chantratita, Wasun (2021) Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Human Genome Variation, 8 (1). ISSN 2054-345X, DOI https://doi.org/10.1038/s41439-021-00135-z <https://doi.org/10.1038/s41439-021-00135-z>. 10.1038/s41439-021-00135-z |
institution |
Universiti Malaya |
building |
UM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaya |
content_source |
UM Research Repository |
url_provider |
http://eprints.um.edu.my/ |
topic |
BF Psychology QH426 Genetics |
spellingShingle |
BF Psychology QH426 Genetics Runcharoen, Chakkaphan Fukunaga, Koya Sensorn, Insee Iemwimangsa, Nareenart Klumsathian, Sommon Tong, Hang Vo, Nam Sy Le, Ly Hlaing, Tin Maung Thant, Myo Mohd Zain, Shamsul Mohamed, Zahurin Pung, Yuh-Fen Capule, Francis Nevado, Jose Silao, Catherine Lynn Al-Mahayri, Zeina N. Ali, Bassam R. Yuliwulandari, Rika Prayuni, Kinasih Zahroh, Hilyatuz Noor, Dzul Azri Mohamed Xangsayarath, Phonepadith Xayavong, Dalouny Kounnavong, Sengchanh Sayasone, Somphou Kordou, Zoe Liopetas, Ioannis Tsikrika, Athina Tsermpini, Evangelia-Eirini Koromina, Maria Mitropoulou, Christina Patrinos, George P. Kesornsit, Aumpika Charoenyingwattana, Angkana Wattanapokayakit, Sukanya Mahasirimongkol, Surakameth Mushiroda, Taisei Chantratita, Wasun Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm) |
description |
Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. A panel of 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using the NGS platform under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Here, we present the frequencies of pharmacogenomic variants and the comparison of these pharmacogenomic variants among different SEA populations and other populations used as controls. We investigated the different types of pharmacogenomic variants, especially those that may have a functional impact. Our results provide substantial genetic variations at 100 pharmacogenomic loci among SEA populations that may contribute to interpopulation variability in drug response phenotypes. Correspondingly, this study provides basic information for further pharmacogenomic investigations in SEA populations. |
format |
Article |
author |
Runcharoen, Chakkaphan Fukunaga, Koya Sensorn, Insee Iemwimangsa, Nareenart Klumsathian, Sommon Tong, Hang Vo, Nam Sy Le, Ly Hlaing, Tin Maung Thant, Myo Mohd Zain, Shamsul Mohamed, Zahurin Pung, Yuh-Fen Capule, Francis Nevado, Jose Silao, Catherine Lynn Al-Mahayri, Zeina N. Ali, Bassam R. Yuliwulandari, Rika Prayuni, Kinasih Zahroh, Hilyatuz Noor, Dzul Azri Mohamed Xangsayarath, Phonepadith Xayavong, Dalouny Kounnavong, Sengchanh Sayasone, Somphou Kordou, Zoe Liopetas, Ioannis Tsikrika, Athina Tsermpini, Evangelia-Eirini Koromina, Maria Mitropoulou, Christina Patrinos, George P. Kesornsit, Aumpika Charoenyingwattana, Angkana Wattanapokayakit, Sukanya Mahasirimongkol, Surakameth Mushiroda, Taisei Chantratita, Wasun |
author_facet |
Runcharoen, Chakkaphan Fukunaga, Koya Sensorn, Insee Iemwimangsa, Nareenart Klumsathian, Sommon Tong, Hang Vo, Nam Sy Le, Ly Hlaing, Tin Maung Thant, Myo Mohd Zain, Shamsul Mohamed, Zahurin Pung, Yuh-Fen Capule, Francis Nevado, Jose Silao, Catherine Lynn Al-Mahayri, Zeina N. Ali, Bassam R. Yuliwulandari, Rika Prayuni, Kinasih Zahroh, Hilyatuz Noor, Dzul Azri Mohamed Xangsayarath, Phonepadith Xayavong, Dalouny Kounnavong, Sengchanh Sayasone, Somphou Kordou, Zoe Liopetas, Ioannis Tsikrika, Athina Tsermpini, Evangelia-Eirini Koromina, Maria Mitropoulou, Christina Patrinos, George P. Kesornsit, Aumpika Charoenyingwattana, Angkana Wattanapokayakit, Sukanya Mahasirimongkol, Surakameth Mushiroda, Taisei Chantratita, Wasun |
author_sort |
Runcharoen, Chakkaphan |
title |
Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm) |
title_short |
Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm) |
title_full |
Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm) |
title_fullStr |
Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm) |
title_full_unstemmed |
Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm) |
title_sort |
prevalence of pharmacogenomic variants in 100 pharmacogenes among southeast asian populations under the collaboration of the southeast asian pharmacogenomics research network (seapharm) |
publisher |
Springernature |
publishDate |
2021 |
url |
http://eprints.um.edu.my/35066/ |
_version_ |
1744649208229527552 |
score |
13.18916 |