Conformational analysis of diterpene lactone andrographolide towards reestablishment of its absolute configuration via theoretical and experimental ecd and vcd methods

• Main Authors: Kadir, Muhamad Faid A., Wibowo, Agustono, Salim, Fatimah, Anouars, El Hassane, Awang, Khalijah, Langat, Moses Kiprotich, Ahmadi, Rohaya
• Format: Article
• Published: Universitas Gadjah Mada 2021
• Subjects: QD Chemistry
• Online Access: http://eprints.um.edu.my/34860/

Andrographolide, the major constituent from the terrestrial plant Andrographis paniculata is a much-studied bioactive ent-labdane diterpene lactone and has become an important medicinal intermediate. As determined by X-ray crystallography, its structure has been applied in molecular docking studies...