Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independ...
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R Medicine RC Internal medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
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R Medicine RC Internal medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer) Conti, David Darst, Burcu F. Moss, Lilit C. Saunders, Edward J. Sheng, Xin Chou, Alisha Schumacher, Fredrick R. Al Olama, Ali Amin Benlloch, Sara Dadaev, Tokhir Brook, Mark N. Sahimi, Ali Hoffmann, Thomas J. Takahashi, Atushi Matsuda, Koichi Momozawa, Yukihide Fujita, Masashi Muir, Kenneth Lophatananon, Artitaya Wan, Peggy Le Marchand, Loic Wilkens, Lynne R. Stevens, Victoria L. Gapstur, Susan M. Carter, Brian D. Schleutker, Johanna Tammela, Teuvo L. J. Sipeky, Csilla Auvinen, Anssi Giles, Graham G. Southey, Melissa C. MacInnis, Robert J. Cybulski, Cezary Wokolorczyk, Dominika Lubinski, Jan Neal, David E. Donovan, Jenny L. Hamdy, Freddie C. Martin, Richard M. Nordestgaard, Borge G. Nielsen, Sune F. Weischer, Maren Bojesen, Stig E. Roder, Martin Andreas Iversen, Peter Batra, Jyotsna Chambers, Suzanne Moya, Leire Horvath, Lisa Clements, Judith A. Tilley, Wayne Risbridger, Gail P. Gronberg, Henrik Aly, Markus Szulkin, Robert Eklund, Martin Nordstrom, Tobias Pashayan, Nora Dunning, Alison M. Ghoussaini, Maya Travis, Ruth C. Key, Tim J. Riboli, Elio Park, Jong Y. Sellers, Thomas A. Lin, Hui-Yi Albanes, Demetrius Weinstein, Stephanie J. Mucci, Lorelei A. Giovannucci, Edward Lindstrom, Sara Kraft, Peter Hunter, David J. Penney, Kathryn L. Turman, Constance Tangen, Catherine M. Goodman, Phyllis J. Thompson, Ian M. Hamilton, Robert J. Fleshner, Neil E. Finelli, Antonio Parent, Marie-Elise Stanford, Janet L. Ostrander, Elaine A. Geybels, Milan S. Koutros, Stella Freeman, Laura E. Beane Stampfer, Meir Wolk, Alicja Hakansson, Niclas Andriole, Gerald L. Hoover, Robert N. Machiela, Mitchell J. Sorensen, Karina Dalsgaard Borre, Michael Blot, William J. Zheng, Wei Yeboah, Edward D. Mensah, James E. Lu, Yong-Jie Zhang, Hong-Wei Feng, Ninghan Mao, Xueying Wu, Yudong Zhao, Shan-Chao Sun, Zan Thibodeau, Stephen N. McDonnell, Shannon K. Schaid, Daniel J. West, Catharine M. L. Burnet, Neil Barnett, Gill Maier, Christiane Schnoeller, Thomas Luedeke, Manuel Kibel, Adam S. Drake, Bettina F. Cussenot, Olivier Cancel-Tassin, Geraldine Menegaux, Florence Truong, Therese Koudou, Yves Akoli John, Esther M. Grindedal, Eli Marie Maehle, Lovise Khaw, Kay-Tee Ingles, Sue A. Stern, Mariana C. Vega, Ana Gomez-Caamano, Antonio Fachal, Laura Rosenstein, Barry S. Kerns, Sarah L. Ostrer, Harry Teixeira, Manuel R. Paulo, Paula Brandao, Andreia Watya, Stephen Lubwama, Alexander Bensen, Jeannette T. Fontham, Elizabeth T. H. Mohler, James Taylor, Jack A. Kogevinas, Manolis Llorca, Javier Castano-Vinyals, Gemma Cannon-Albright, Lisa Teerlink, Craig C. Huff, Chad D. Strom, Sara S. Multigner, Luc Blanchet, Pascal Brureau, Laurent Kaneva, Radka Slavov, Chavdar Mitev, Vanio Leach, Robin J. Weaver, Brandi Brenner, Hermann Cuk, Katarina Holleczek, Bernd Saum, Kai-Uwe Klein, Eric A. Hsing, Ann W. Kittles, Rick A. Murphy, Adam B. Logothetis, Christopher J. Kim, Jeri Neuhausen, Susan L. Steele, Linda Ding, Yuan Chun Isaacs, William B. Nemesure, Barbara Hennis, Anselm J. M. Carpten, John Pandha, Hardev Michael, Agnieszka De Ruyck, Kim De Meerleer, Gert Ost, Piet Xu, Jianfeng Razack, Azad Hassan Abdul Lim, Jasmine Teo, Soo-Hwang Newcomb, Lisa F. Lin, Daniel W. Fowke, Jay H. Neslund-Dudas, Christine Rybicki, Benjamin A. Gamulin, Marija Lessel, Davor Kulis, Tomislav Usmani, Nawaid Singhal, Sandeep Parliament, Matthew Claessens, Frank Joniau, Steven Van den Broeck, Thomas Gago-Dominguez, Manuela Castelao, Jose Esteban Martinez, Maria Elena Larkin, Samantha Townsend, Paul A. Aukim-Hastie, Claire Bush, William S. Aldrich, Melinda C. Crawford, Dana C. Srivastava, Shiv Cullen, Jennifer C. Petrovics, Gyorgy Casey, Graham Roobol, Monique J. Jenster, Guido van Schaik, Ron H. N. Hu, Jennifer J. Sanderson, Maureen Varma, Rohit McKean-Cowdin, Roberta Torres, Mina Mancuso, Nicholas Berndt, Sonja Van den Eeden, Stephen K. Easton, Douglas F. Chanock, Stephen J. Cook, Michael B. Wiklund, Fredrik Nakagawa, Hidewaki Witte, John S. Eeles, Rosalind A. Kote-Jarai, Zsofia Haiman, Christopher A. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction |
description |
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries. |
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Conti, David Darst, Burcu F. Moss, Lilit C. Saunders, Edward J. Sheng, Xin Chou, Alisha Schumacher, Fredrick R. Al Olama, Ali Amin Benlloch, Sara Dadaev, Tokhir Brook, Mark N. Sahimi, Ali Hoffmann, Thomas J. Takahashi, Atushi Matsuda, Koichi Momozawa, Yukihide Fujita, Masashi Muir, Kenneth Lophatananon, Artitaya Wan, Peggy Le Marchand, Loic Wilkens, Lynne R. Stevens, Victoria L. Gapstur, Susan M. Carter, Brian D. Schleutker, Johanna Tammela, Teuvo L. J. Sipeky, Csilla Auvinen, Anssi Giles, Graham G. Southey, Melissa C. MacInnis, Robert J. Cybulski, Cezary Wokolorczyk, Dominika Lubinski, Jan Neal, David E. Donovan, Jenny L. Hamdy, Freddie C. Martin, Richard M. Nordestgaard, Borge G. Nielsen, Sune F. Weischer, Maren Bojesen, Stig E. Roder, Martin Andreas Iversen, Peter Batra, Jyotsna Chambers, Suzanne Moya, Leire Horvath, Lisa Clements, Judith A. Tilley, Wayne Risbridger, Gail P. Gronberg, Henrik Aly, Markus Szulkin, Robert Eklund, Martin Nordstrom, Tobias Pashayan, Nora Dunning, Alison M. Ghoussaini, Maya Travis, Ruth C. Key, Tim J. Riboli, Elio Park, Jong Y. Sellers, Thomas A. Lin, Hui-Yi Albanes, Demetrius Weinstein, Stephanie J. Mucci, Lorelei A. Giovannucci, Edward Lindstrom, Sara Kraft, Peter Hunter, David J. Penney, Kathryn L. Turman, Constance Tangen, Catherine M. Goodman, Phyllis J. Thompson, Ian M. Hamilton, Robert J. Fleshner, Neil E. Finelli, Antonio Parent, Marie-Elise Stanford, Janet L. Ostrander, Elaine A. Geybels, Milan S. Koutros, Stella Freeman, Laura E. Beane Stampfer, Meir Wolk, Alicja Hakansson, Niclas Andriole, Gerald L. Hoover, Robert N. Machiela, Mitchell J. Sorensen, Karina Dalsgaard Borre, Michael Blot, William J. Zheng, Wei Yeboah, Edward D. Mensah, James E. Lu, Yong-Jie Zhang, Hong-Wei Feng, Ninghan Mao, Xueying Wu, Yudong Zhao, Shan-Chao Sun, Zan Thibodeau, Stephen N. McDonnell, Shannon K. Schaid, Daniel J. West, Catharine M. L. Burnet, Neil Barnett, Gill Maier, Christiane Schnoeller, Thomas Luedeke, Manuel Kibel, Adam S. Drake, Bettina F. Cussenot, Olivier Cancel-Tassin, Geraldine Menegaux, Florence Truong, Therese Koudou, Yves Akoli John, Esther M. Grindedal, Eli Marie Maehle, Lovise Khaw, Kay-Tee Ingles, Sue A. Stern, Mariana C. Vega, Ana Gomez-Caamano, Antonio Fachal, Laura Rosenstein, Barry S. Kerns, Sarah L. Ostrer, Harry Teixeira, Manuel R. Paulo, Paula Brandao, Andreia Watya, Stephen Lubwama, Alexander Bensen, Jeannette T. Fontham, Elizabeth T. H. Mohler, James Taylor, Jack A. Kogevinas, Manolis Llorca, Javier Castano-Vinyals, Gemma Cannon-Albright, Lisa Teerlink, Craig C. Huff, Chad D. Strom, Sara S. Multigner, Luc Blanchet, Pascal Brureau, Laurent Kaneva, Radka Slavov, Chavdar Mitev, Vanio Leach, Robin J. Weaver, Brandi Brenner, Hermann Cuk, Katarina Holleczek, Bernd Saum, Kai-Uwe Klein, Eric A. Hsing, Ann W. Kittles, Rick A. Murphy, Adam B. Logothetis, Christopher J. Kim, Jeri Neuhausen, Susan L. Steele, Linda Ding, Yuan Chun Isaacs, William B. Nemesure, Barbara Hennis, Anselm J. M. Carpten, John Pandha, Hardev Michael, Agnieszka De Ruyck, Kim De Meerleer, Gert Ost, Piet Xu, Jianfeng Razack, Azad Hassan Abdul Lim, Jasmine Teo, Soo-Hwang Newcomb, Lisa F. Lin, Daniel W. Fowke, Jay H. Neslund-Dudas, Christine Rybicki, Benjamin A. Gamulin, Marija Lessel, Davor Kulis, Tomislav Usmani, Nawaid Singhal, Sandeep Parliament, Matthew Claessens, Frank Joniau, Steven Van den Broeck, Thomas Gago-Dominguez, Manuela Castelao, Jose Esteban Martinez, Maria Elena Larkin, Samantha Townsend, Paul A. Aukim-Hastie, Claire Bush, William S. Aldrich, Melinda C. Crawford, Dana C. Srivastava, Shiv Cullen, Jennifer C. Petrovics, Gyorgy Casey, Graham Roobol, Monique J. Jenster, Guido van Schaik, Ron H. N. Hu, Jennifer J. Sanderson, Maureen Varma, Rohit McKean-Cowdin, Roberta Torres, Mina Mancuso, Nicholas Berndt, Sonja Van den Eeden, Stephen K. Easton, Douglas F. Chanock, Stephen J. Cook, Michael B. Wiklund, Fredrik Nakagawa, Hidewaki Witte, John S. Eeles, Rosalind A. Kote-Jarai, Zsofia Haiman, Christopher A. |
author_facet |
Conti, David Darst, Burcu F. Moss, Lilit C. Saunders, Edward J. Sheng, Xin Chou, Alisha Schumacher, Fredrick R. Al Olama, Ali Amin Benlloch, Sara Dadaev, Tokhir Brook, Mark N. Sahimi, Ali Hoffmann, Thomas J. Takahashi, Atushi Matsuda, Koichi Momozawa, Yukihide Fujita, Masashi Muir, Kenneth Lophatananon, Artitaya Wan, Peggy Le Marchand, Loic Wilkens, Lynne R. Stevens, Victoria L. Gapstur, Susan M. Carter, Brian D. Schleutker, Johanna Tammela, Teuvo L. J. Sipeky, Csilla Auvinen, Anssi Giles, Graham G. Southey, Melissa C. MacInnis, Robert J. Cybulski, Cezary Wokolorczyk, Dominika Lubinski, Jan Neal, David E. Donovan, Jenny L. Hamdy, Freddie C. Martin, Richard M. Nordestgaard, Borge G. Nielsen, Sune F. Weischer, Maren Bojesen, Stig E. Roder, Martin Andreas Iversen, Peter Batra, Jyotsna Chambers, Suzanne Moya, Leire Horvath, Lisa Clements, Judith A. Tilley, Wayne Risbridger, Gail P. Gronberg, Henrik Aly, Markus Szulkin, Robert Eklund, Martin Nordstrom, Tobias Pashayan, Nora Dunning, Alison M. Ghoussaini, Maya Travis, Ruth C. Key, Tim J. Riboli, Elio Park, Jong Y. Sellers, Thomas A. Lin, Hui-Yi Albanes, Demetrius Weinstein, Stephanie J. Mucci, Lorelei A. Giovannucci, Edward Lindstrom, Sara Kraft, Peter Hunter, David J. Penney, Kathryn L. Turman, Constance Tangen, Catherine M. Goodman, Phyllis J. Thompson, Ian M. Hamilton, Robert J. Fleshner, Neil E. Finelli, Antonio Parent, Marie-Elise Stanford, Janet L. Ostrander, Elaine A. Geybels, Milan S. Koutros, Stella Freeman, Laura E. Beane Stampfer, Meir Wolk, Alicja Hakansson, Niclas Andriole, Gerald L. Hoover, Robert N. Machiela, Mitchell J. Sorensen, Karina Dalsgaard Borre, Michael Blot, William J. Zheng, Wei Yeboah, Edward D. Mensah, James E. Lu, Yong-Jie Zhang, Hong-Wei Feng, Ninghan Mao, Xueying Wu, Yudong Zhao, Shan-Chao Sun, Zan Thibodeau, Stephen N. McDonnell, Shannon K. Schaid, Daniel J. West, Catharine M. L. Burnet, Neil Barnett, Gill Maier, Christiane Schnoeller, Thomas Luedeke, Manuel Kibel, Adam S. Drake, Bettina F. Cussenot, Olivier Cancel-Tassin, Geraldine Menegaux, Florence Truong, Therese Koudou, Yves Akoli John, Esther M. Grindedal, Eli Marie Maehle, Lovise Khaw, Kay-Tee Ingles, Sue A. Stern, Mariana C. Vega, Ana Gomez-Caamano, Antonio Fachal, Laura Rosenstein, Barry S. Kerns, Sarah L. Ostrer, Harry Teixeira, Manuel R. Paulo, Paula Brandao, Andreia Watya, Stephen Lubwama, Alexander Bensen, Jeannette T. Fontham, Elizabeth T. H. Mohler, James Taylor, Jack A. Kogevinas, Manolis Llorca, Javier Castano-Vinyals, Gemma Cannon-Albright, Lisa Teerlink, Craig C. Huff, Chad D. Strom, Sara S. Multigner, Luc Blanchet, Pascal Brureau, Laurent Kaneva, Radka Slavov, Chavdar Mitev, Vanio Leach, Robin J. Weaver, Brandi Brenner, Hermann Cuk, Katarina Holleczek, Bernd Saum, Kai-Uwe Klein, Eric A. Hsing, Ann W. Kittles, Rick A. Murphy, Adam B. Logothetis, Christopher J. Kim, Jeri Neuhausen, Susan L. Steele, Linda Ding, Yuan Chun Isaacs, William B. Nemesure, Barbara Hennis, Anselm J. M. Carpten, John Pandha, Hardev Michael, Agnieszka De Ruyck, Kim De Meerleer, Gert Ost, Piet Xu, Jianfeng Razack, Azad Hassan Abdul Lim, Jasmine Teo, Soo-Hwang Newcomb, Lisa F. Lin, Daniel W. Fowke, Jay H. Neslund-Dudas, Christine Rybicki, Benjamin A. Gamulin, Marija Lessel, Davor Kulis, Tomislav Usmani, Nawaid Singhal, Sandeep Parliament, Matthew Claessens, Frank Joniau, Steven Van den Broeck, Thomas Gago-Dominguez, Manuela Castelao, Jose Esteban Martinez, Maria Elena Larkin, Samantha Townsend, Paul A. Aukim-Hastie, Claire Bush, William S. Aldrich, Melinda C. Crawford, Dana C. Srivastava, Shiv Cullen, Jennifer C. Petrovics, Gyorgy Casey, Graham Roobol, Monique J. Jenster, Guido van Schaik, Ron H. N. Hu, Jennifer J. Sanderson, Maureen Varma, Rohit McKean-Cowdin, Roberta Torres, Mina Mancuso, Nicholas Berndt, Sonja Van den Eeden, Stephen K. Easton, Douglas F. Chanock, Stephen J. Cook, Michael B. Wiklund, Fredrik Nakagawa, Hidewaki Witte, John S. Eeles, Rosalind A. Kote-Jarai, Zsofia Haiman, Christopher A. |
author_sort |
Conti, David |
title |
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction |
title_short |
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction |
title_full |
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction |
title_fullStr |
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction |
title_full_unstemmed |
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction |
title_sort |
trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
http://eprints.um.edu.my/34720/ |
_version_ |
1744649196026200064 |
spelling |
my.um.eprints.347202022-09-19T06:51:00Z http://eprints.um.edu.my/34720/ Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction Conti, David Darst, Burcu F. Moss, Lilit C. Saunders, Edward J. Sheng, Xin Chou, Alisha Schumacher, Fredrick R. Al Olama, Ali Amin Benlloch, Sara Dadaev, Tokhir Brook, Mark N. Sahimi, Ali Hoffmann, Thomas J. Takahashi, Atushi Matsuda, Koichi Momozawa, Yukihide Fujita, Masashi Muir, Kenneth Lophatananon, Artitaya Wan, Peggy Le Marchand, Loic Wilkens, Lynne R. Stevens, Victoria L. Gapstur, Susan M. Carter, Brian D. Schleutker, Johanna Tammela, Teuvo L. J. Sipeky, Csilla Auvinen, Anssi Giles, Graham G. Southey, Melissa C. MacInnis, Robert J. Cybulski, Cezary Wokolorczyk, Dominika Lubinski, Jan Neal, David E. Donovan, Jenny L. Hamdy, Freddie C. Martin, Richard M. Nordestgaard, Borge G. Nielsen, Sune F. Weischer, Maren Bojesen, Stig E. Roder, Martin Andreas Iversen, Peter Batra, Jyotsna Chambers, Suzanne Moya, Leire Horvath, Lisa Clements, Judith A. Tilley, Wayne Risbridger, Gail P. Gronberg, Henrik Aly, Markus Szulkin, Robert Eklund, Martin Nordstrom, Tobias Pashayan, Nora Dunning, Alison M. Ghoussaini, Maya Travis, Ruth C. Key, Tim J. Riboli, Elio Park, Jong Y. Sellers, Thomas A. Lin, Hui-Yi Albanes, Demetrius Weinstein, Stephanie J. Mucci, Lorelei A. Giovannucci, Edward Lindstrom, Sara Kraft, Peter Hunter, David J. Penney, Kathryn L. Turman, Constance Tangen, Catherine M. Goodman, Phyllis J. Thompson, Ian M. Hamilton, Robert J. Fleshner, Neil E. Finelli, Antonio Parent, Marie-Elise Stanford, Janet L. Ostrander, Elaine A. Geybels, Milan S. Koutros, Stella Freeman, Laura E. Beane Stampfer, Meir Wolk, Alicja Hakansson, Niclas Andriole, Gerald L. Hoover, Robert N. Machiela, Mitchell J. Sorensen, Karina Dalsgaard Borre, Michael Blot, William J. Zheng, Wei Yeboah, Edward D. Mensah, James E. Lu, Yong-Jie Zhang, Hong-Wei Feng, Ninghan Mao, Xueying Wu, Yudong Zhao, Shan-Chao Sun, Zan Thibodeau, Stephen N. McDonnell, Shannon K. Schaid, Daniel J. West, Catharine M. L. Burnet, Neil Barnett, Gill Maier, Christiane Schnoeller, Thomas Luedeke, Manuel Kibel, Adam S. Drake, Bettina F. Cussenot, Olivier Cancel-Tassin, Geraldine Menegaux, Florence Truong, Therese Koudou, Yves Akoli John, Esther M. Grindedal, Eli Marie Maehle, Lovise Khaw, Kay-Tee Ingles, Sue A. Stern, Mariana C. Vega, Ana Gomez-Caamano, Antonio Fachal, Laura Rosenstein, Barry S. Kerns, Sarah L. Ostrer, Harry Teixeira, Manuel R. Paulo, Paula Brandao, Andreia Watya, Stephen Lubwama, Alexander Bensen, Jeannette T. Fontham, Elizabeth T. H. Mohler, James Taylor, Jack A. Kogevinas, Manolis Llorca, Javier Castano-Vinyals, Gemma Cannon-Albright, Lisa Teerlink, Craig C. Huff, Chad D. Strom, Sara S. Multigner, Luc Blanchet, Pascal Brureau, Laurent Kaneva, Radka Slavov, Chavdar Mitev, Vanio Leach, Robin J. Weaver, Brandi Brenner, Hermann Cuk, Katarina Holleczek, Bernd Saum, Kai-Uwe Klein, Eric A. Hsing, Ann W. Kittles, Rick A. Murphy, Adam B. Logothetis, Christopher J. Kim, Jeri Neuhausen, Susan L. Steele, Linda Ding, Yuan Chun Isaacs, William B. Nemesure, Barbara Hennis, Anselm J. M. Carpten, John Pandha, Hardev Michael, Agnieszka De Ruyck, Kim De Meerleer, Gert Ost, Piet Xu, Jianfeng Razack, Azad Hassan Abdul Lim, Jasmine Teo, Soo-Hwang Newcomb, Lisa F. Lin, Daniel W. Fowke, Jay H. Neslund-Dudas, Christine Rybicki, Benjamin A. Gamulin, Marija Lessel, Davor Kulis, Tomislav Usmani, Nawaid Singhal, Sandeep Parliament, Matthew Claessens, Frank Joniau, Steven Van den Broeck, Thomas Gago-Dominguez, Manuela Castelao, Jose Esteban Martinez, Maria Elena Larkin, Samantha Townsend, Paul A. Aukim-Hastie, Claire Bush, William S. Aldrich, Melinda C. Crawford, Dana C. Srivastava, Shiv Cullen, Jennifer C. Petrovics, Gyorgy Casey, Graham Roobol, Monique J. Jenster, Guido van Schaik, Ron H. N. Hu, Jennifer J. Sanderson, Maureen Varma, Rohit McKean-Cowdin, Roberta Torres, Mina Mancuso, Nicholas Berndt, Sonja Van den Eeden, Stephen K. Easton, Douglas F. Chanock, Stephen J. Cook, Michael B. Wiklund, Fredrik Nakagawa, Hidewaki Witte, John S. Eeles, Rosalind A. Kote-Jarai, Zsofia Haiman, Christopher A. R Medicine RC Internal medicine RC0254 Neoplasms. Tumors. Oncology (including Cancer) Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. A meta-analysis of genome-wide association studies across different populations highlights new risk loci and provides a genetic risk score that can stratify prostate cancer risk across ancestries. Nature Portfolio 2021-01 Article PeerReviewed Conti, David and Darst, Burcu F. and Moss, Lilit C. and Saunders, Edward J. and Sheng, Xin and Chou, Alisha and Schumacher, Fredrick R. and Al Olama, Ali Amin and Benlloch, Sara and Dadaev, Tokhir and Brook, Mark N. and Sahimi, Ali and Hoffmann, Thomas J. and Takahashi, Atushi and Matsuda, Koichi and Momozawa, Yukihide and Fujita, Masashi and Muir, Kenneth and Lophatananon, Artitaya and Wan, Peggy and Le Marchand, Loic and Wilkens, Lynne R. and Stevens, Victoria L. and Gapstur, Susan M. and Carter, Brian D. and Schleutker, Johanna and Tammela, Teuvo L. J. and Sipeky, Csilla and Auvinen, Anssi and Giles, Graham G. and Southey, Melissa C. and MacInnis, Robert J. and Cybulski, Cezary and Wokolorczyk, Dominika and Lubinski, Jan and Neal, David E. and Donovan, Jenny L. and Hamdy, Freddie C. and Martin, Richard M. and Nordestgaard, Borge G. and Nielsen, Sune F. and Weischer, Maren and Bojesen, Stig E. and Roder, Martin Andreas and Iversen, Peter and Batra, Jyotsna and Chambers, Suzanne and Moya, Leire and Horvath, Lisa and Clements, Judith A. and Tilley, Wayne and Risbridger, Gail P. and Gronberg, Henrik and Aly, Markus and Szulkin, Robert and Eklund, Martin and Nordstrom, Tobias and Pashayan, Nora and Dunning, Alison M. and Ghoussaini, Maya and Travis, Ruth C. and Key, Tim J. and Riboli, Elio and Park, Jong Y. and Sellers, Thomas A. and Lin, Hui-Yi and Albanes, Demetrius and Weinstein, Stephanie J. and Mucci, Lorelei A. and Giovannucci, Edward and Lindstrom, Sara and Kraft, Peter and Hunter, David J. and Penney, Kathryn L. and Turman, Constance and Tangen, Catherine M. and Goodman, Phyllis J. and Thompson, Ian M. and Hamilton, Robert J. and Fleshner, Neil E. and Finelli, Antonio and Parent, Marie-Elise and Stanford, Janet L. and Ostrander, Elaine A. and Geybels, Milan S. and Koutros, Stella and Freeman, Laura E. Beane and Stampfer, Meir and Wolk, Alicja and Hakansson, Niclas and Andriole, Gerald L. and Hoover, Robert N. and Machiela, Mitchell J. and Sorensen, Karina Dalsgaard and Borre, Michael and Blot, William J. and Zheng, Wei and Yeboah, Edward D. and Mensah, James E. and Lu, Yong-Jie and Zhang, Hong-Wei and Feng, Ninghan and Mao, Xueying and Wu, Yudong and Zhao, Shan-Chao and Sun, Zan and Thibodeau, Stephen N. and McDonnell, Shannon K. and Schaid, Daniel J. and West, Catharine M. L. and Burnet, Neil and Barnett, Gill and Maier, Christiane and Schnoeller, Thomas and Luedeke, Manuel and Kibel, Adam S. and Drake, Bettina F. and Cussenot, Olivier and Cancel-Tassin, Geraldine and Menegaux, Florence and Truong, Therese and Koudou, Yves Akoli and John, Esther M. and Grindedal, Eli Marie and Maehle, Lovise and Khaw, Kay-Tee and Ingles, Sue A. and Stern, Mariana C. and Vega, Ana and Gomez-Caamano, Antonio and Fachal, Laura and Rosenstein, Barry S. and Kerns, Sarah L. and Ostrer, Harry and Teixeira, Manuel R. and Paulo, Paula and Brandao, Andreia and Watya, Stephen and Lubwama, Alexander and Bensen, Jeannette T. and Fontham, Elizabeth T. 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