Metabolic perturbations prior to hepatocellular carcinoma diagnosis: Findings from a prospective observational cohort study

• Main Authors: Stepien, Magdalena, Keski-Rahkonen, Pekka, Kiss, Agneta, Robinot, Nivonirina, Duarte-Salles, Talita, Murphy, Neil, Perlemuter, Gabriel, Viallon, Vivian, Tjonneland, Anne, Rostgaard-Hansen, Agnetha Linn, Dahm, Christina C., Overvad, Kim, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahannat-Saleh, Yahya, Aleksandrova, Krasimira, Kaaks, Rudolf, Kuehn, Tilman, Trichopoulou, Antonia, Karakatsani, Anna, Panico, Salvatore, Tumino, Rosario, Palli, Domenico, Tagliabue, Giovanna, Naccarati, Alessio, Vermeulen, Roel C. H., Bueno-de-Mesquita, Hendrik Bastiaan, Weiderpass, Elisabete, Skeie, Guri, Ramon Quiros, Jose, Ardanaz, Eva, Mokoroa, Olatz, Sala, Nuria, Sanchez, Maria-Jose, Maria Huerta, Jose, Winkvist, Anna, Harlid, Sophia, Ohlsson, Bodil, Sjoberg, Klas, Schmidt, Julie A., Wareham, Nick, Khaw, Kay-Tee, Ferrari, Pietro, Rothwell, Joseph A., Gunter, Marc, Riboli, Elio, Scalbert, Augustin, Jenab, Mazda
• Format: Article
• Published: Wiley 2021
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.um.edu.my/34710/

Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect m...