Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-kappa B activation and immune escape

• Main Authors: Bruce, Jeff P., To, Ka-Fai, Lui, Vivian W. Y., Chung, Grace T. Y., Chan, Yuk-Yu, Tsang, Chi Man, Yip, Kevin Y., Ma, Brigette B. Y., Woo, John K. S., Hui, Edwin P., Mak, Michael K. F., Lee, Sau-Dan, Chow, Chit, Velapasamy, Sharmila, Or, Yvonne Y. Y., Siu, Pui Kei, El Ghamrasni, Samah, Prokopec, Stephenie, Wu, Man, Kwan, Johnny S. H., Liu, Yuchen, Chan, Jason Y. K., van Hasselt, C. Andrew, Young, Lawrence S., Dawson, Christopher W., Paterson, Ian C., Yap, Lee-Fah, Tsao, Sai-Wah, Liu, Fei-Fei, Chan, Anthony T. C., Pugh, Trevor J., Lo, Kwok-Wai
• Format: Article
• Published: Nature Portfolio 2021
• Subjects: R Medicine; RA Public aspects of medicine; RK Dentistry
• Online Access: http://eprints.um.edu.my/34686/

Interplay between EBV infection and acquired genetic alterations during nasopharyngeal carcinoma (NPC) development remains vague. Here we report a comprehensive genomic analysis of 70 NPCs, combining whole-genome sequencing (WGS) of microdissected tumor cells with EBV oncogene expression to reveal m...