Development of flexible electrochemical impedance spectroscopy-based biosensing platform for rapid screening of SARS-CoV-2 inhibitors

• Main Authors: Kiew, Lik-Voon, Chang, Chia-Yu, Huang, Sheng-Yu, Wang, Pei-Wen, Heh, Choon-Han, Liu, Chung-Te, Cheng, Chia-Hsin, Lu, Yi-Xiang, Chen, Yen-Chen, Huang, Yi-Xuan, Chang, Sheng-Yun, Tsai, Huei-Yu, Kung, Yu-An, Huang, Peng-Nien, Hsu, Ming-Hua, Leo, Bey-Fen, Foo, Yiing-Yee, Su, Chien-Hao, Hsu, Kuo-Chen, Huang, Po-Hsun, Ng, Chirk-Jenn, Kamarulzaman, Adeeba, Yuan, Chiun-Jye, Shieh, Dar-Bin, Shih, Shin-Ru, Chung, Lip-Yong, Chang, Chia-Ching
• Format: Article
• Published: Elsevier Advanced Technology 2021
• Subjects: QC Physics; R Medicine; TP Chemical technology
• Online Access: http://eprints.um.edu.my/34622/

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the cells through the binding of its spike protein (S-protein) to the cell surface-expressing angiotensin-converting enzyme 2 (ACE2). Thus, inhibition of S-protein-ACE2 binding may impede SARS-CoV-2 cell entry and attenuate the prog...