Contemporary approaches to the discovery and development of broad-spectrum natural product prototypes for the control of coronaviruses

• Main Authors: Hanna, George S., Choo, Yeun-Mun, Harbit, Ryan, Paeth, Heather, Wilde, Sarah, Mackle, James, Verga, Jacopo-Umberto, Wolf, Bethany J., Thomas, Olivier P., Croot, Peter, Cray, James, Thomas, Courtney, Li, Ling-Zhi, Hardiman, Gary, Hu, Jin-Feng, Wang, Xiaojuan, Patel, Dharmeshkumar, Schinazi, Raymond F., O'Keefe, Barry R., Hamann, Mark T.
• Format: Article
• Published: American Chemical Society 2021
• Subjects: QD Chemistry; R Medicine
• Online Access: http://eprints.um.edu.my/34611/

The pressing need for SARS-CoV-2 controls has led to a reassessment of strategies to identify and develop natural product inhibitors of zoonotic, highly virulent, and rapidly emerging viruses. This review article addresses how contemporary approaches involving computational chemistry, natural produc...