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A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp

A new antimalarial sterol, kaimanol (1), along with a known sterol, saringosterol (2) was isolated from the Indonesian Marine sponge, Xestospongia sp. The chemical structure of the new compound was determined on the basis of spectroscopic evidences and by comparison to those related compounds previo...

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Main Authors: Murtihapsari, Salam, Supriatno, Kurnia, Dikdik, Darwati, Kadarusman, Abdullah, Fajar Fauzi, Herlina, Tati, Husna, Muhammad Hafiz, Awang, Khalijah, Shiono, Yoshihito, Azmi, Mohamad Nurul, Supratman, Unang
Format: Article
Published: Taylor & Francis 2021
Subjects:
QD Chemistry
Online Access:http://eprints.um.edu.my/34542/
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spelling my.um.eprints.345422022-09-15T01:36:34Z http://eprints.um.edu.my/34542/ A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp Murtihapsari Salam, Supriatno Kurnia, Dikdik Darwati Kadarusman Abdullah, Fajar Fauzi Herlina, Tati Husna, Muhammad Hafiz Awang, Khalijah Shiono, Yoshihito Azmi, Mohamad Nurul Supratman, Unang QD Chemistry A new antimalarial sterol, kaimanol (1), along with a known sterol, saringosterol (2) was isolated from the Indonesian Marine sponge, Xestospongia sp. The chemical structure of the new compound was determined on the basis of spectroscopic evidences and by comparison to those related compounds previously reported. Isolated compounds, 1 and 2 were evaluated for their antiplasmodial effect against Plasmodium falciparum 3D7 strains. Compounds 1 and 2 exhibited antiplasmodial activity with IC50 values of 359 and 0.250 nM, respectively. GRAPHICS] . Taylor & Francis 2021-03-19 Article PeerReviewed Murtihapsari and Salam, Supriatno and Kurnia, Dikdik and Darwati and Kadarusman and Abdullah, Fajar Fauzi and Herlina, Tati and Husna, Muhammad Hafiz and Awang, Khalijah and Shiono, Yoshihito and Azmi, Mohamad Nurul and Supratman, Unang (2021) A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp. Natural Product Research, 35 (6). pp. 937-944. ISSN 1478-6419, DOI https://doi.org/10.1080/14786419.2019.1611815 <https://doi.org/10.1080/14786419.2019.1611815>. 10.1080/14786419.2019.1611815
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
spellingShingle QD Chemistry
Murtihapsari
Salam, Supriatno
Kurnia, Dikdik
Darwati
Kadarusman
Abdullah, Fajar Fauzi
Herlina, Tati
Husna, Muhammad Hafiz
Awang, Khalijah
Shiono, Yoshihito
Azmi, Mohamad Nurul
Supratman, Unang
A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp
description A new antimalarial sterol, kaimanol (1), along with a known sterol, saringosterol (2) was isolated from the Indonesian Marine sponge, Xestospongia sp. The chemical structure of the new compound was determined on the basis of spectroscopic evidences and by comparison to those related compounds previously reported. Isolated compounds, 1 and 2 were evaluated for their antiplasmodial effect against Plasmodium falciparum 3D7 strains. Compounds 1 and 2 exhibited antiplasmodial activity with IC50 values of 359 and 0.250 nM, respectively. GRAPHICS] .
format Article
author Murtihapsari
Salam, Supriatno
Kurnia, Dikdik
Darwati
Kadarusman
Abdullah, Fajar Fauzi
Herlina, Tati
Husna, Muhammad Hafiz
Awang, Khalijah
Shiono, Yoshihito
Azmi, Mohamad Nurul
Supratman, Unang
author_facet Murtihapsari
Salam, Supriatno
Kurnia, Dikdik
Darwati
Kadarusman
Abdullah, Fajar Fauzi
Herlina, Tati
Husna, Muhammad Hafiz
Awang, Khalijah
Shiono, Yoshihito
Azmi, Mohamad Nurul
Supratman, Unang
author_sort Murtihapsari
title A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp
title_short A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp
title_full A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp
title_fullStr A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp
title_full_unstemmed A new antiplasmodial sterol from Indonesian marine sponge, Xestospongia sp
title_sort new antiplasmodial sterol from indonesian marine sponge, xestospongia sp
publisher Taylor & Francis
publishDate 2021
url http://eprints.um.edu.my/34542/
_version_ 1744649185688289280
score 13.209306

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