Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains
Sera of IgA nephropathy (IgAN) patients and normal subjects were analysed by two-dimensional (2-D) gel electrophoresis. Densitometric analysis of the 2-D gels of IgAN patients and normal subjects revealed that their protein maps were comparable. There was no shift of pI values in the major alpha-hea...
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my.um.eprints.34462019-10-24T08:15:10Z http://eprints.um.edu.my/3446/ Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains Shuib, A.S. Chua, C.T. Hashim, Onn Haji R Medicine Sera of IgA nephropathy (IgAN) patients and normal subjects were analysed by two-dimensional (2-D) gel electrophoresis. Densitometric analysis of the 2-D gels of IgAN patients and normal subjects revealed that their protein maps were comparable. There was no shift of pI values in the major alpha-heavy chain spots. However, the volume of the alpha-heavy chain bands were differently distributed. Distribution was significantly lower at the anionic region in IgAN patients (mean anionic:cationic ratio of 1.184 +/- 0.311) as compared to normal healthy controls (mean anionic:cationic ratio of 2.139 +/- 0.538). Our data are in support of the previously reported findings that IgA1 of IgAN patients were lacking in sialic acid residues. 1998 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3446/1/Sera_of_IgA_nephropathy_patients_contain_a_heterogeneous_population_of_relatively_cationic_alpha-heavy_chains.pdf Shuib, A.S. and Chua, C.T. and Hashim, Onn Haji (1998) Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains. Nephron, 78 (3). pp. 290-295. ISSN 0028-2766 http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000044938 10.1159/000044938 |
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R Medicine Shuib, A.S. Chua, C.T. Hashim, Onn Haji Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains |
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Sera of IgA nephropathy (IgAN) patients and normal subjects were analysed by two-dimensional (2-D) gel electrophoresis. Densitometric analysis of the 2-D gels of IgAN patients and normal subjects revealed that their protein maps were comparable. There was no shift of pI values in the major alpha-heavy chain spots. However, the volume of the alpha-heavy chain bands were differently distributed. Distribution was significantly lower at the anionic region in IgAN patients (mean anionic:cationic ratio of 1.184 +/- 0.311) as compared to normal healthy controls (mean anionic:cationic ratio of 2.139 +/- 0.538). Our data are in support of the previously reported findings that IgA1 of IgAN patients were lacking in sialic acid residues. |
format |
Article |
author |
Shuib, A.S. Chua, C.T. Hashim, Onn Haji |
author_facet |
Shuib, A.S. Chua, C.T. Hashim, Onn Haji |
author_sort |
Shuib, A.S. |
title |
Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains |
title_short |
Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains |
title_full |
Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains |
title_fullStr |
Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains |
title_full_unstemmed |
Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains |
title_sort |
sera of iga nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains |
publishDate |
1998 |
url |
http://eprints.um.edu.my/3446/1/Sera_of_IgA_nephropathy_patients_contain_a_heterogeneous_population_of_relatively_cationic_alpha-heavy_chains.pdf http://eprints.um.edu.my/3446/ http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000044938 |
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1648735992588271616 |
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13.18916 |