RSK1 vs. RSK2 inhibitory activity of the marine beta-carboline alkaloid Manzamine A: A biochemical, cervical cancer protein expression, and computational study

• Main Authors: Mayer, Alejandro M. S., Hall, Mary L., Lach, Joseph, Clifford, Jonathan, Chandrasena, Kevin, Canton, Caitlin, Kontoyianni, Maria, Choo, Yeun-Mun, Karan, Dev, Hamann, Mark T.
• Format: Article
• Published: MDPI 2021
• Subjects: R Medicine; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/34368/

Manzamines are complex polycyclic marine-derived beta-carboline alkaloids with reported anticancer, immunostimulatory, anti-inflammatory, antibacterial, antiviral, antimalarial, neuritogenic, hyperlipidemia, and atherosclerosis suppression bioactivities, putatively associated with inhibition of glyc...