Alkyl-resorcinol derivatives as inhibitors of gdp-mannose pyrophosphorylase with antileishmanial activities

• Main Authors: Levaique, Helene, Pamlard, Olivier, Apel, Cecile, Bignon, Jerome, Arriola, Margaux, Kuhner, Robin, Awang, Khalijah, Loiseau, Philippe M., Litaudon, Marc, Pomel, Sebastien
• Format: Article
• Published: MDPI 2021
• Subjects: QD Chemistry; QH301 Biology
• Online Access: http://eprints.um.edu.my/34364/

Leishmaniasis is a vector-borne disease caused by the protozoan parasite Leishmania found in tropical and sub-tropical areas, affecting 12 million people around the world. Only few treatments are available against this disease and all of them present issues of toxicity and/or resistance. In this con...