Extraintestinal manifestation of inflammatory bowel disease in Asian patients: A multinational study

Background/aim: Although inflammatory bowel disease (IBD) incidence has increased over the past two decades in Asia, data on extraintestinal manifestations (EIMs) of IBD in Asian patients are limited. We aimed to evaluate the prevalence and clinical characteristics of EIMs in Asian IBD patients. Met...

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Main Authors: Park, Soo-Kyung, Wong, Zhiqin, Park, Sang Hyoung, Vu, Khien Van, Bang, Ki Bae, Piyachaturawat, Panida, Myint, Thein, Hilmi, Ida Normiha, Park, Dong-Il
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Published: Elsevier 2021
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Online Access:http://eprints.um.edu.my/34244/
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spelling my.um.eprints.342442022-06-16T04:14:33Z http://eprints.um.edu.my/34244/ Extraintestinal manifestation of inflammatory bowel disease in Asian patients: A multinational study Park, Soo-Kyung Wong, Zhiqin Park, Sang Hyoung Vu, Khien Van Bang, Ki Bae Piyachaturawat, Panida Myint, Thein Hilmi, Ida Normiha Park, Dong-Il R Medicine RA Public aspects of medicine Background/aim: Although inflammatory bowel disease (IBD) incidence has increased over the past two decades in Asia, data on extraintestinal manifestations (EIMs) of IBD in Asian patients are limited. We aimed to evaluate the prevalence and clinical characteristics of EIMs in Asian IBD patients. Methods: In total, 1,764 patients (1,130 with ulcerative colitis UC] and 634 with Crohn's disease CD]) were recruited from 10 tertiary centers in Asia. The medical records of IBD patients were retrospectively reviewed for the presence, clinical characteristics, chronological order, and therapeutic management of EIMs. Results: EIMs were reported in 199 (11.3%) patients, of which 17 (1.0%) patients had multiple EIMs. EIMs were more prevalent in CD patients (P = 0.02). Multiple logistic regression analysis revealed that female sex (odds ratio OR] 2.02, 95% confidence interval CI] 1.15-3.55), stricture (OR 2.49, 95% CI 1.41-4.39) and female sex (OR 2.57, 95% CI 1.52-4.34), extensive colitis (OR 2.63, 95% CI 1.57-4.41) were associated with EIMs in CD and UC patients respectively. EIMs appeared in 8% of patients before IBD diagnosis; 95% of cases with EIM could be managed via first-line therapy. Conclusion: EIM prevalence is lower among Asian IBD patients than among patients from Western countries; however, the risk factors for EIM were similar between both populations. (C) 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. Elsevier 2021-02 Article PeerReviewed Park, Soo-Kyung and Wong, Zhiqin and Park, Sang Hyoung and Vu, Khien Van and Bang, Ki Bae and Piyachaturawat, Panida and Myint, Thein and Hilmi, Ida Normiha and Park, Dong-Il (2021) Extraintestinal manifestation of inflammatory bowel disease in Asian patients: A multinational study. Digestive and Liver Disease, 53 (2). pp. 196-201. ISSN 1125-8055, DOI https://doi.org/10.1016/j.dld.2020.06.046 <https://doi.org/10.1016/j.dld.2020.06.046>. 10.1016/j.dld.2020.06.046
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
RA Public aspects of medicine
spellingShingle R Medicine
RA Public aspects of medicine
Park, Soo-Kyung
Wong, Zhiqin
Park, Sang Hyoung
Vu, Khien Van
Bang, Ki Bae
Piyachaturawat, Panida
Myint, Thein
Hilmi, Ida Normiha
Park, Dong-Il
Extraintestinal manifestation of inflammatory bowel disease in Asian patients: A multinational study
description Background/aim: Although inflammatory bowel disease (IBD) incidence has increased over the past two decades in Asia, data on extraintestinal manifestations (EIMs) of IBD in Asian patients are limited. We aimed to evaluate the prevalence and clinical characteristics of EIMs in Asian IBD patients. Methods: In total, 1,764 patients (1,130 with ulcerative colitis UC] and 634 with Crohn's disease CD]) were recruited from 10 tertiary centers in Asia. The medical records of IBD patients were retrospectively reviewed for the presence, clinical characteristics, chronological order, and therapeutic management of EIMs. Results: EIMs were reported in 199 (11.3%) patients, of which 17 (1.0%) patients had multiple EIMs. EIMs were more prevalent in CD patients (P = 0.02). Multiple logistic regression analysis revealed that female sex (odds ratio OR] 2.02, 95% confidence interval CI] 1.15-3.55), stricture (OR 2.49, 95% CI 1.41-4.39) and female sex (OR 2.57, 95% CI 1.52-4.34), extensive colitis (OR 2.63, 95% CI 1.57-4.41) were associated with EIMs in CD and UC patients respectively. EIMs appeared in 8% of patients before IBD diagnosis; 95% of cases with EIM could be managed via first-line therapy. Conclusion: EIM prevalence is lower among Asian IBD patients than among patients from Western countries; however, the risk factors for EIM were similar between both populations. (C) 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
format Article
author Park, Soo-Kyung
Wong, Zhiqin
Park, Sang Hyoung
Vu, Khien Van
Bang, Ki Bae
Piyachaturawat, Panida
Myint, Thein
Hilmi, Ida Normiha
Park, Dong-Il
author_facet Park, Soo-Kyung
Wong, Zhiqin
Park, Sang Hyoung
Vu, Khien Van
Bang, Ki Bae
Piyachaturawat, Panida
Myint, Thein
Hilmi, Ida Normiha
Park, Dong-Il
author_sort Park, Soo-Kyung
title Extraintestinal manifestation of inflammatory bowel disease in Asian patients: A multinational study
title_short Extraintestinal manifestation of inflammatory bowel disease in Asian patients: A multinational study
title_full Extraintestinal manifestation of inflammatory bowel disease in Asian patients: A multinational study
title_fullStr Extraintestinal manifestation of inflammatory bowel disease in Asian patients: A multinational study
title_full_unstemmed Extraintestinal manifestation of inflammatory bowel disease in Asian patients: A multinational study
title_sort extraintestinal manifestation of inflammatory bowel disease in asian patients: a multinational study
publisher Elsevier
publishDate 2021
url http://eprints.um.edu.my/34244/
_version_ 1738510716972826624
score 13.187197