Absence of BapA type III effector protein affects Burkholderia pseudomallei intracellular lifecycle in human host cells

• Main Authors: Choh, Leang-Chung, Ong, Guang-Han, Chua, Eng-Guan, Vellasamy, Kumutha Malar, Mariappan, Vanitha, Khan, Asif M., Wise, Micheal J., Wong, Kum-Thong, Vadivelu, Jamuna
• Format: Article
• Published: Elsevier 2021
• Subjects: Q Science (General); R Medicine; T Technology (General)
• Online Access: http://eprints.um.edu.my/34171/

The etiological agent of melioidosis, Burkholderia pseudomallei, utilises a type III secretion system cluster 3 (T3SS3) to deliver proteins termed type III effectors (T3SEs) into the host cytoplasm in order to establish an intracellular lifecycle in phagocytic and non-phagocytic cells, thus playing...