Enantioseparation of ketoconazole and miconazole by capillary electrophoresis and a study on their inclusion interactions with beta-cyclodextrin and derivatives

• Main Authors: Azhari, Nurul Raihana, Yahaya, Noorfatimah, Mohd Suah, Faiz Bukhari M., Prabu, Samikannu, Yih Hui, Boon, Shahriman, Mohamad Shariff, Mohamad Zain, Nur Nadhirah, Ramachandran, Muggundha Raoov
• Format: Article
• Published: WILEY 2021
• Subjects: QD Chemistry; RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/33971/

A chiral separation method coupled with capillary electrophoresis (CE) analysis for ketoconazole and miconazole enantiomers using chiral selectors such as beta-cyclodextrin (beta-CD) and hydroxypropyl-beta-CD (HP-beta-CD) was developed in this study, which included the optimisation, validation and a...