Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia

Background and Objectives: One major source of antibiotic contamination in the sea is from aquaculture. We monitored the concentration of commonly used antibiotic classes and antibiotic resistance genes (tet(M), sul1, sul2 and sul3) in aquaculture farms in Peninsular Malaysia. Methods: Antibiotic re...

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Main Authors: Thiang, Ee Lean, Lee, Choon Weng, Takada, Hideshige, Seki, Kanako, Takei, Ayaka, Suzuki, Satoru, Wang, Aijun, Bong, Chui Wei
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Published: Taylor & Francis Inc 2021
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Online Access:http://eprints.um.edu.my/33964/
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spelling my.um.eprints.339642022-07-08T00:58:38Z http://eprints.um.edu.my/33964/ Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia Thiang, Ee Lean Lee, Choon Weng Takada, Hideshige Seki, Kanako Takei, Ayaka Suzuki, Satoru Wang, Aijun Bong, Chui Wei GE Environmental Sciences QH Natural history Background and Objectives: One major source of antibiotic contamination in the sea is from aquaculture. We monitored the concentration of commonly used antibiotic classes and antibiotic resistance genes (tet(M), sul1, sul2 and sul3) in aquaculture farms in Peninsular Malaysia. Methods: Antibiotic residues and resistance genes were quantified using high-performance liquid chromatography and real-time PCR respectively. Risk quotients in European technical guidance document on risk assessment was used to assess the potential environmental risk. Results: We detected 23 antibiotics with tetracyclines, sulfonamides and quinolones were the most frequently detected classes, indicating a wide distribution of antibiotics in Malaysian aquaculture farms. The dendrogram and heatmap revealed three groups of antibiotic concentration patterns but with no differences in the types of antibiotics usage among aquaculture farms. The ARGs (10(-3) copies/16S) were detected in >90% of the sites except for sul3. Ciprofloxacin, enrofloxacin, norfloxacin and lincomycin posed risks to cyanobacteria and algae in Kelantan, Perak and Pahang. Conclusion: Relative to Asian aquaculture farms, the residues detected here were at low or moderate levels except for quinolones. This study will be useful to develop effective management of aquaculture wastewater in order to mitigate antibiotic pollution and transmission of ARGs to humans through the food chain. Taylor & Francis Inc 2021-01-01 Article PeerReviewed Thiang, Ee Lean and Lee, Choon Weng and Takada, Hideshige and Seki, Kanako and Takei, Ayaka and Suzuki, Satoru and Wang, Aijun and Bong, Chui Wei (2021) Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia. Ecosystem Health and Sustainability, 7 (1). ISSN 2096-4129, DOI https://doi.org/10.1080/20964129.2021.1926337 <https://doi.org/10.1080/20964129.2021.1926337>. 10.1080/20964129.2021.1926337
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic GE Environmental Sciences
QH Natural history
spellingShingle GE Environmental Sciences
QH Natural history
Thiang, Ee Lean
Lee, Choon Weng
Takada, Hideshige
Seki, Kanako
Takei, Ayaka
Suzuki, Satoru
Wang, Aijun
Bong, Chui Wei
Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia
description Background and Objectives: One major source of antibiotic contamination in the sea is from aquaculture. We monitored the concentration of commonly used antibiotic classes and antibiotic resistance genes (tet(M), sul1, sul2 and sul3) in aquaculture farms in Peninsular Malaysia. Methods: Antibiotic residues and resistance genes were quantified using high-performance liquid chromatography and real-time PCR respectively. Risk quotients in European technical guidance document on risk assessment was used to assess the potential environmental risk. Results: We detected 23 antibiotics with tetracyclines, sulfonamides and quinolones were the most frequently detected classes, indicating a wide distribution of antibiotics in Malaysian aquaculture farms. The dendrogram and heatmap revealed three groups of antibiotic concentration patterns but with no differences in the types of antibiotics usage among aquaculture farms. The ARGs (10(-3) copies/16S) were detected in >90% of the sites except for sul3. Ciprofloxacin, enrofloxacin, norfloxacin and lincomycin posed risks to cyanobacteria and algae in Kelantan, Perak and Pahang. Conclusion: Relative to Asian aquaculture farms, the residues detected here were at low or moderate levels except for quinolones. This study will be useful to develop effective management of aquaculture wastewater in order to mitigate antibiotic pollution and transmission of ARGs to humans through the food chain.
format Article
author Thiang, Ee Lean
Lee, Choon Weng
Takada, Hideshige
Seki, Kanako
Takei, Ayaka
Suzuki, Satoru
Wang, Aijun
Bong, Chui Wei
author_facet Thiang, Ee Lean
Lee, Choon Weng
Takada, Hideshige
Seki, Kanako
Takei, Ayaka
Suzuki, Satoru
Wang, Aijun
Bong, Chui Wei
author_sort Thiang, Ee Lean
title Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia
title_short Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia
title_full Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia
title_fullStr Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia
title_full_unstemmed Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia
title_sort antibiotic residues from aquaculture farms and their ecological risks in southeast asia: a case study from malaysia
publisher Taylor & Francis Inc
publishDate 2021
url http://eprints.um.edu.my/33964/
_version_ 1738510695618576384
score 13.209306