Towards a selective cytotoxic agent for prostate cancer: interaction of zinc complexes of polyhydroxybenzaldehyde thiosemicarbazones with topoisomerase I

• Main Authors: Tan, K.W., Seng, H.L., Lim, F.S., Cheah, S.C., Ng, C.H., Koo, K.S., Mustafa, Mohd Rais, Ng, S.W., Maah, M.J.
• Format: Article
• Language: English
• Published: 2012
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/3295/1/Towards_a_selective_cytotoxic_agent_for_prostate_cancer_Interaction_of_zinc.pdf; http://eprints.um.edu.my/3295/; http://www.sciencedirect.com/science/article/pii/S0277538712001404

Four thiosemicarbazones ligands,H3T(1),H3M(2),H3E(3) andH3P(4) have been prepared with good yield by refluxing 2,4-dihydroxybenzaldehyde with N(4)-substituted thiosemicarbazide in ethanol (H3T(1) = 2,4-dihydroxybenzaldehyde thiosemicarbazone;H3M(2) = 2,4-dihydroxybenzaldehyde 4-methylthiosemicarbazo...