Vasodilator effect of phlomis bracteosa constituents is mediated through dual Endothelium-Dependent and Endothelium-Independent pathways

• Main Authors: Khan, A., Ullah, R., Mustafa, Mohd Rais, Hussain, J., Murugan, D.D., Hadi, A.H.B.A.
• Format: Article
• Language: English
• Published: 2012
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/3294/1/Vasodilator_Effect_of_Phlomis_bracteosa_Constituents_Is.pdf; http://eprints.um.edu.my/3294/; http://informahealthcare.com/doi/abs/10.3109/10641963.2011.601383

This study describes the vasorelaxant potential of some pure compounds isolated from Phlomis bracteosa L.: marrubiin, phlomeoic acid, and two new constituents labeled as RA and RB. In rat thoracic aortic rings denuded of endothelium, marrubiin, phlomeoic acid, RA, and RB caused relaxation of high K+...