In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF-�ºB translocation

• Main Authors: Abdelwahab, S.I., Koko, W.S., Taha, M.M.E., Mohan, S., Achoui, M., Abdulla, M.A., Mustafa, Mohd Rais, Ahmad, S., Noordin, M.I., Yong, C.L.
• Format: Article
• Language: English
• Published: 2011
• Subjects: QD Chemistry; RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/3021/1/In_vitro_and_in_vivo_anti-inflammatory_activities_of_columbin_through_the_inhibition_of.pdf; http://eprints.um.edu.my/3021/; http://www.sciencedirect.com/science/article/pii/S0014299911015585

Columbin, a diterpenoid furanolactone, was isolated purely for the first time from the plant species Tinspora bakis. The anti-inflammatory effects of columbin were studied in vitro, in silico and in vivo. The effect of columbin on nitric oxide was examined on lipopolysaccharide�interferon-gamma (L...