Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiffbases in rats
The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, (1)H NMR, (13)C NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compound...
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my.um.eprints.29072019-01-30T01:34:19Z http://eprints.um.edu.my/2907/ Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiffbases in rats Salga, M.S. Ali, Hapipah Mohd Abdulla, M.A. Abdelwahab, S.I. QD Chemistry The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, (1)H NMR, (13)C NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compounds was performed orally to the rats at the single doses of 2000 mg/kg and they were then monitored for possible side effects, mortality or behavioral changes up to 14 days. The serum level of aspartate (AST), alanine aminotransferases (ALT), alkaline phosphate (ALP), triglyceride, high density lipoprotein (HDL), immunoglobulins (GAM) and the C-reactive proteins did not significantly change. The hematological indices white blood cells (WBC), haematocrit (HCT), red blood cells (RBC), mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) were within the normal range. The renal function indices examined were also within the reference range. Generally, the compounds exhibited low toxic effects as required for further in vivo therapeutic studies. 2012-01 Article PeerReviewed Salga, M.S. and Ali, Hapipah Mohd and Abdulla, M.A. and Abdelwahab, S.I. (2012) Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiffbases in rats. International Journal of Molecular Sciences, 13 (2). ISSN 1422-0067 http://www.ncbi.nlm.nih.gov/pubmed/22408397 PMID: 22408397 |
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QD Chemistry Salga, M.S. Ali, Hapipah Mohd Abdulla, M.A. Abdelwahab, S.I. Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiffbases in rats |
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The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, (1)H NMR, (13)C NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compounds was performed orally to the rats at the single doses of 2000 mg/kg and they were then monitored for possible side effects, mortality or behavioral changes up to 14 days. The serum level of aspartate (AST), alanine aminotransferases (ALT), alkaline phosphate (ALP), triglyceride, high density lipoprotein (HDL), immunoglobulins (GAM) and the C-reactive proteins did not significantly change. The hematological indices white blood cells (WBC), haematocrit (HCT), red blood cells (RBC), mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) were within the normal range. The renal function indices examined were also within the reference range. Generally, the compounds exhibited low toxic effects as required for further in vivo therapeutic studies. |
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Article |
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Salga, M.S. Ali, Hapipah Mohd Abdulla, M.A. Abdelwahab, S.I. |
author_facet |
Salga, M.S. Ali, Hapipah Mohd Abdulla, M.A. Abdelwahab, S.I. |
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Salga, M.S. |
title |
Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiffbases in rats |
title_short |
Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiffbases in rats |
title_full |
Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiffbases in rats |
title_fullStr |
Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiffbases in rats |
title_full_unstemmed |
Acute oral toxicity evaluations of some Zinc(II) complexes derived from 1-(2-Salicylaldiminoethyl)piperazine Schiffbases in rats |
title_sort |
acute oral toxicity evaluations of some zinc(ii) complexes derived from 1-(2-salicylaldiminoethyl)piperazine schiffbases in rats |
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2012 |
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http://eprints.um.edu.my/2907/ http://www.ncbi.nlm.nih.gov/pubmed/22408397 |
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