Molecular mechanism of L-SP40 peptide and in vivo efficacy against EV-A71 in neonatal mice

• Main Authors: Lalani, Salima, Tan, Soon Hao, Tan, Kuan Onn, Lim, Hui Xuan, Ong, Kien Chai, Wong, Kum Thong, Poh, Chit Laa
• Format: Article
• Published: Pergamon-Elsevier Science Ltd 2021
• Subjects: R Medicine (General)
• Online Access: http://eprints.um.edu.my/28662/

Aims: Enterovirus A71 (EV-A71) is an etiological agent of hand foot and mouth disease (HFMD) and has the potential to cause severe neurological infections in children. L-SP40 peptide was previously known to inhibit EVA71 by prophylactic action. This study aimed to identify the mechanism of inhibitio...