Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions
This study aims to evaluate the diagnostic accuracy of digital breast tomosynthesis-guided vacuum-assisted breast biopsy (DBT-VABB) of screening-detected suspicious mammographic abnormalities comprising of calcifications, asymmetric densities, architectural distortions, and spiculated masses. In thi...
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my.um.eprints.286372022-03-24T04:18:29Z http://eprints.um.edu.my/28637/ Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions Bohan, Suhaila Hamid, Marlina Tanty Ramli Chan, Wai Yee Vijayananthan, Anushya Ramli, Norlisah Kaur, Shaleen Rahmat, Kartini R Medicine This study aims to evaluate the diagnostic accuracy of digital breast tomosynthesis-guided vacuum-assisted breast biopsy (DBT-VABB) of screening-detected suspicious mammographic abnormalities comprising of calcifications, asymmetric densities, architectural distortions, and spiculated masses. In this institutionally approved study, a total of 170 (n=170) DBT-VABB were performed, 153 (90%) were for calcifications, 8 (4.7%) for spiculated mass, 5 (2.9%) for asymmetric density and 4 (2.4%) for architectural distortion. All these lesions were not detected on the corresponding ultrasound. Histopathology results revealed 140 (82.4%) benign, 9 (5.3%) borderline and 21 (12.4%) malignant lesions. The total upgrade rate at surgery was 40% for atypical ductal hyperplasia and 5.9% for ductal carcinoma in-situ. 3.6% discordant benign lesions showed no upgrade. DBT-VABB showed 100% specificity, 91.3% sensitivity and 100% positive predictive value (PPV) for detecting malignant lesions. The negative predictive value (NPV) was 80%. 2 (1.2%) patients had mild complications and 1 (0.6%) had severe pain. Our study showed that DBT-VABB was a safe and reliable method, with high sensitivity, specificity, PPV, and NPV in the diagnosis of non-palpable benign and malignant breast lesions. Our data also confirmed the accuracy of DBT-VABB in detecting malignant lesions and we suggest further surgical excision in borderline lesions for a more accurate diagnostic evaluation. Nature Research 2021 Article PeerReviewed Bohan, Suhaila and Hamid, Marlina Tanty Ramli and Chan, Wai Yee and Vijayananthan, Anushya and Ramli, Norlisah and Kaur, Shaleen and Rahmat, Kartini (2021) Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions. Scientific Reports, 11 (1). ISSN 2045-2322, DOI https://doi.org/10.1038/s41598-020-80124-4 <https://doi.org/10.1038/s41598-020-80124-4>. 10.1038/s41598-020-80124-4 |
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R Medicine Bohan, Suhaila Hamid, Marlina Tanty Ramli Chan, Wai Yee Vijayananthan, Anushya Ramli, Norlisah Kaur, Shaleen Rahmat, Kartini Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions |
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This study aims to evaluate the diagnostic accuracy of digital breast tomosynthesis-guided vacuum-assisted breast biopsy (DBT-VABB) of screening-detected suspicious mammographic abnormalities comprising of calcifications, asymmetric densities, architectural distortions, and spiculated masses. In this institutionally approved study, a total of 170 (n=170) DBT-VABB were performed, 153 (90%) were for calcifications, 8 (4.7%) for spiculated mass, 5 (2.9%) for asymmetric density and 4 (2.4%) for architectural distortion. All these lesions were not detected on the corresponding ultrasound. Histopathology results revealed 140 (82.4%) benign, 9 (5.3%) borderline and 21 (12.4%) malignant lesions. The total upgrade rate at surgery was 40% for atypical ductal hyperplasia and 5.9% for ductal carcinoma in-situ. 3.6% discordant benign lesions showed no upgrade. DBT-VABB showed 100% specificity, 91.3% sensitivity and 100% positive predictive value (PPV) for detecting malignant lesions. The negative predictive value (NPV) was 80%. 2 (1.2%) patients had mild complications and 1 (0.6%) had severe pain. Our study showed that DBT-VABB was a safe and reliable method, with high sensitivity, specificity, PPV, and NPV in the diagnosis of non-palpable benign and malignant breast lesions. Our data also confirmed the accuracy of DBT-VABB in detecting malignant lesions and we suggest further surgical excision in borderline lesions for a more accurate diagnostic evaluation. |
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Article |
author |
Bohan, Suhaila Hamid, Marlina Tanty Ramli Chan, Wai Yee Vijayananthan, Anushya Ramli, Norlisah Kaur, Shaleen Rahmat, Kartini |
author_facet |
Bohan, Suhaila Hamid, Marlina Tanty Ramli Chan, Wai Yee Vijayananthan, Anushya Ramli, Norlisah Kaur, Shaleen Rahmat, Kartini |
author_sort |
Bohan, Suhaila |
title |
Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions |
title_short |
Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions |
title_full |
Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions |
title_fullStr |
Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions |
title_full_unstemmed |
Diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions |
title_sort |
diagnostic accuracy of tomosynthesis-guided vacuum assisted breast biopsy of ultrasound occult lesions |
publisher |
Nature Research |
publishDate |
2021 |
url |
http://eprints.um.edu.my/28637/ |
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1735409566023155712 |
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13.160551 |