Comparison of preoperative nutritional indexes for outcomes after primary esophageal surgery for esophageal squamous cell carcinoma
Background: This study aimed to compare the controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and geriatric nutritional risk index (GNRI) for predicting postoperative outcomes in patients with esophageal squamous cell carcinoma undergoing esophagectomy. Methods: We re...
Saved in:
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Published: |
MDPI
2021
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/28568/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.um.eprints.28568 |
---|---|
record_format |
eprints |
spelling |
my.um.eprints.285682022-03-14T03:09:47Z http://eprints.um.edu.my/28568/ Comparison of preoperative nutritional indexes for outcomes after primary esophageal surgery for esophageal squamous cell carcinoma Yoon, Jung-Pil Nam, Jae-Sik Zainal Abidin, Mohd Fitry Kim, Seon-Ok Lee, Eun-Ho Choi, In-Cheol Chin, Ji-Hyun QP Physiology Background: This study aimed to compare the controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and geriatric nutritional risk index (GNRI) for predicting postoperative outcomes in patients with esophageal squamous cell carcinoma undergoing esophagectomy. Methods: We retrospectively reviewed the data of 1265 consecutive patients who underwent elective esophageal surgery. The patients were classified into no risk, low-risk, moderate-risk, and high-risk groups based on nutritional scores. Results: The moderate-risk (hazard ratio HR]: 1.55, 95% confidence interval CI]: 1.24-1.92, p < 0.001 in CONUT; HR: 1.61, 95% CI: 1.22-2.12, p = 0.001 in GNRI; HR: 1.65, 95% CI: 1.20-2.26, p = 0.002 in PNI) and high-risk groups (HR: 1.91, 95% CI: 1.47-2.48, p < 0.001 in CONUT; HR: 2.54, 95% CI: 1.64-3.93, p < 0.001 in GNRI; HR: 2.32, 95% CI: 1.77-3.06, p < 0.001 in PNI) exhibited significantly worse 5-year overall survival (OS) compared with the no-risk group. As the nutritional status worsened, the trend in the OS rates decreased (p for trend in all indexes < 0.05). Conclusions: Malnutrition, evaluated by any of three nutritional indexes, was an independent prognostic factor for postoperative survival. MDPI 2021-11 Article PeerReviewed Yoon, Jung-Pil and Nam, Jae-Sik and Zainal Abidin, Mohd Fitry and Kim, Seon-Ok and Lee, Eun-Ho and Choi, In-Cheol and Chin, Ji-Hyun (2021) Comparison of preoperative nutritional indexes for outcomes after primary esophageal surgery for esophageal squamous cell carcinoma. Nutrients, 13 (11). ISSN 2072-6643, DOI https://doi.org/10.3390/nu13114086 <https://doi.org/10.3390/nu13114086>. 10.3390/nu13114086 |
institution |
Universiti Malaya |
building |
UM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Malaya |
content_source |
UM Research Repository |
url_provider |
http://eprints.um.edu.my/ |
topic |
QP Physiology |
spellingShingle |
QP Physiology Yoon, Jung-Pil Nam, Jae-Sik Zainal Abidin, Mohd Fitry Kim, Seon-Ok Lee, Eun-Ho Choi, In-Cheol Chin, Ji-Hyun Comparison of preoperative nutritional indexes for outcomes after primary esophageal surgery for esophageal squamous cell carcinoma |
description |
Background: This study aimed to compare the controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and geriatric nutritional risk index (GNRI) for predicting postoperative outcomes in patients with esophageal squamous cell carcinoma undergoing esophagectomy. Methods: We retrospectively reviewed the data of 1265 consecutive patients who underwent elective esophageal surgery. The patients were classified into no risk, low-risk, moderate-risk, and high-risk groups based on nutritional scores. Results: The moderate-risk (hazard ratio HR]: 1.55, 95% confidence interval CI]: 1.24-1.92, p < 0.001 in CONUT; HR: 1.61, 95% CI: 1.22-2.12, p = 0.001 in GNRI; HR: 1.65, 95% CI: 1.20-2.26, p = 0.002 in PNI) and high-risk groups (HR: 1.91, 95% CI: 1.47-2.48, p < 0.001 in CONUT; HR: 2.54, 95% CI: 1.64-3.93, p < 0.001 in GNRI; HR: 2.32, 95% CI: 1.77-3.06, p < 0.001 in PNI) exhibited significantly worse 5-year overall survival (OS) compared with the no-risk group. As the nutritional status worsened, the trend in the OS rates decreased (p for trend in all indexes < 0.05). Conclusions: Malnutrition, evaluated by any of three nutritional indexes, was an independent prognostic factor for postoperative survival. |
format |
Article |
author |
Yoon, Jung-Pil Nam, Jae-Sik Zainal Abidin, Mohd Fitry Kim, Seon-Ok Lee, Eun-Ho Choi, In-Cheol Chin, Ji-Hyun |
author_facet |
Yoon, Jung-Pil Nam, Jae-Sik Zainal Abidin, Mohd Fitry Kim, Seon-Ok Lee, Eun-Ho Choi, In-Cheol Chin, Ji-Hyun |
author_sort |
Yoon, Jung-Pil |
title |
Comparison of preoperative nutritional indexes for outcomes after primary esophageal surgery for esophageal squamous cell carcinoma |
title_short |
Comparison of preoperative nutritional indexes for outcomes after primary esophageal surgery for esophageal squamous cell carcinoma |
title_full |
Comparison of preoperative nutritional indexes for outcomes after primary esophageal surgery for esophageal squamous cell carcinoma |
title_fullStr |
Comparison of preoperative nutritional indexes for outcomes after primary esophageal surgery for esophageal squamous cell carcinoma |
title_full_unstemmed |
Comparison of preoperative nutritional indexes for outcomes after primary esophageal surgery for esophageal squamous cell carcinoma |
title_sort |
comparison of preoperative nutritional indexes for outcomes after primary esophageal surgery for esophageal squamous cell carcinoma |
publisher |
MDPI |
publishDate |
2021 |
url |
http://eprints.um.edu.my/28568/ |
_version_ |
1735409558730309632 |
score |
13.159267 |