Liquid chromatography-tandem mass spectrometry method for the determination of vardenafil and its application of bioequivalence

• Main Authors: Gan, Kok Zheng, Widodo, Riyanto Teguh, Chik, Zamri, Teh, Lay Kek, Rofiee, Mohd Salleh, Mohamad Yusof, Mohd Izwan
• Format: Article
• Published: Hindawi Ltd 2021
• Subjects: QD Chemistry; RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/28427/

A simple, rapid, and sensitive method of liquid chromatography-tandem mass spectrometry (LC/MS/MS) method was developed and validated for the determination of vardenafil in rabbit plasma. A simple protein precipitation method with ice-cold acetonitrile was used for plasma extraction. The mass transi...