CYP3A5 genetic variants and their associations with carbamazepine and valproic acid response in Malaysian epileptic patients

• Main Authors: Miyata-Nozaka, Yuka, Tan, Hui Jan, Wong, Sau Wei, Raymond, Azman Ali, Omar, Haslyna, Zain, Shamsul Mohd
• Format: Article
• Published: Dustri-Verlag 2021
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/28350/

Objective: Epilepsy is a common chronic neurological condition characterized by recurrent seizures. Approximately 30 - 40% of epileptic patients do not respond to antiepileptic drugs. Previous studies suggest that CYP3A5 polymorphisms affect carbamazepine metabolism. Materials and methods: To examin...