Allium sativum mitigates oxidative damages induced by Microcystin-LR in heart and liver tissues of mice

• Main Authors: Abderrahim, Leila Ait, Taibi, Khaled, Boussaid, Mohamed, Al-Shara, Baker, Abderrahim, Nawel Ait, Abderrahim, Sabrina Ait
• Format: Article
• Published: Pergamon-Elsevier Science Ltd 2021
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://eprints.um.edu.my/28183/

Microcystins (MCs) are hepatotoxic cyanotoxins implicated in several incidents of human and animal toxicity. Microcystin-(Lysine, Arginine) or MC-LR is the most toxic and encountered variant of MCs where oxidative stress plays a key role in its toxicity. This study investigated the oxidative damages induced in the liver and heart of Balb/C mice by an intraperitoneal injected acute dose of MC-LR. Thereafter, the potential protective effect of garlic (Allium sativum) extract supplementation against such damages was assessed through the evaluation of oxidative stress and cytotoxicity markers. Lipid peroxidation (LPO), carbonyl content (CC), glutathione content (GSH), alkaline phosphatase activity (ALP), lactate dehydrogenase (LDH) and sorbitol dehydrogenase (SDH) activities were measured. Results showed important oxidative damages in hepatic and cardiac cells of mice injected with the toxin. However, these damages have been significantly reduced in mice supplemented with garlic extract. Thus, this study demonstrated for the first time the effective use of garlic as an antioxidant agent against oxidative damages induced by MC-LR. As well, this study supports the use of garlic as a potential remedy against pathologies related to toxic agents.