Raman spectroscopy as process analytical tool in downstream processing of biotechnology
Downstream processing or product recovery plays a vital role in the development of bioprocesses. To improve the bioprocess efficiency, some unconventional methods are much required. The continuous manufacturing in downstream processing makes the Process Analytical Technologies (PATs) as an important...
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my.um.eprints.280962022-07-25T01:54:44Z http://eprints.um.edu.my/28096/ Raman spectroscopy as process analytical tool in downstream processing of biotechnology Lin, Yu Kiat Leong, Hui Yi Ling, Tau Chuan Lin, Dong-Qiang Yao, Shan-Jing QH301 Biology TA Engineering (General). Civil engineering (General) Downstream processing or product recovery plays a vital role in the development of bioprocesses. To improve the bioprocess efficiency, some unconventional methods are much required. The continuous manufacturing in downstream processing makes the Process Analytical Technologies (PATs) as an important tool. Monitoring and controlling bioprocess are an essential factor for the principles of PAT and quality by design. Spectroscopic methods can apply to monitor multiple analytes in real-time with less sample processing with significant advancements. Raman spectroscopy is an extensively used technique as an analytical and research tool owing to its modest process form, non-destructive, non-invasive optical molecular spectroscopic imaging with computer-based analysis. Generally, its application is essential for the analysis and characterization of biological samples, and it is easy to operate with minimal sample. The innovation on various types of enhanced Raman spectroscopy was designed to enhance the Raman analytical technique. Raman spectroscopy could couple with chemometrics to provide reliable alternative analysis method of downstream process analysis. Thus, this review aims to provide useful insight on the application of Raman spectroscopy for PAT in downstream processing of biotechnology and Raman data analysis in biological fields. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved. Chinese Journal of Chemical Engineering 2021-02 Article PeerReviewed Lin, Yu Kiat and Leong, Hui Yi and Ling, Tau Chuan and Lin, Dong-Qiang and Yao, Shan-Jing (2021) Raman spectroscopy as process analytical tool in downstream processing of biotechnology. Chinese Journal of Chemical Engineering, 30. pp. 204-211. ISSN 1004-9541, DOI https://doi.org/10.1016/j.cjche.2020.12.008 <https://doi.org/10.1016/j.cjche.2020.12.008>. 10.1016/j.cjche.2020.12.008 |
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QH301 Biology TA Engineering (General). Civil engineering (General) Lin, Yu Kiat Leong, Hui Yi Ling, Tau Chuan Lin, Dong-Qiang Yao, Shan-Jing Raman spectroscopy as process analytical tool in downstream processing of biotechnology |
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Downstream processing or product recovery plays a vital role in the development of bioprocesses. To improve the bioprocess efficiency, some unconventional methods are much required. The continuous manufacturing in downstream processing makes the Process Analytical Technologies (PATs) as an important tool. Monitoring and controlling bioprocess are an essential factor for the principles of PAT and quality by design. Spectroscopic methods can apply to monitor multiple analytes in real-time with less sample processing with significant advancements. Raman spectroscopy is an extensively used technique as an analytical and research tool owing to its modest process form, non-destructive, non-invasive optical molecular spectroscopic imaging with computer-based analysis. Generally, its application is essential for the analysis and characterization of biological samples, and it is easy to operate with minimal sample. The innovation on various types of enhanced Raman spectroscopy was designed to enhance the Raman analytical technique. Raman spectroscopy could couple with chemometrics to provide reliable alternative analysis method of downstream process analysis. Thus, this review aims to provide useful insight on the application of Raman spectroscopy for PAT in downstream processing of biotechnology and Raman data analysis in biological fields. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved. |
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Article |
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Lin, Yu Kiat Leong, Hui Yi Ling, Tau Chuan Lin, Dong-Qiang Yao, Shan-Jing |
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Lin, Yu Kiat Leong, Hui Yi Ling, Tau Chuan Lin, Dong-Qiang Yao, Shan-Jing |
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Lin, Yu Kiat |
title |
Raman spectroscopy as process analytical tool in downstream processing of biotechnology |
title_short |
Raman spectroscopy as process analytical tool in downstream processing of biotechnology |
title_full |
Raman spectroscopy as process analytical tool in downstream processing of biotechnology |
title_fullStr |
Raman spectroscopy as process analytical tool in downstream processing of biotechnology |
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Raman spectroscopy as process analytical tool in downstream processing of biotechnology |
title_sort |
raman spectroscopy as process analytical tool in downstream processing of biotechnology |
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Chinese Journal of Chemical Engineering |
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2021 |
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http://eprints.um.edu.my/28096/ |
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13.18916 |