Transforming growth factor-β impairs glucocorticoid activity in the A549 lung adenocarcinoma cell line

• Main Authors: Salem, S., Harris, T., Mok, S.L., Li, M.Y., Keenan, C.R., Schuliga, M.J., Stewart, A.G.
• Format: Article
• Published: 2012
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/2789/; http://www.ncbi.nlm.nih.gov/pubmed/22300324

Background and purpose. The lung adenocarcinoma cell line, A549, undergoes epithelial mesenchymal cell transition (EMT) in response to transforming growth factor-β (TGF-β). Glucocorticoids did not prevent the EMT response, but TGF-β induced resistance to the cytokine-regulatory action of glucocorti...